Risk factors of hepatic function alterations in hospitalized adult patients treated with short-term parenteral nutrition receiving the same lipid composition at the same dose

Table 5 Univariate analysis showing liver test variations and risk factors: differences between the beginning and end of treatment

LT variations	R²	B	95% CI	p Linear regression
Days of follow-up (with PN)
GGT	0.041	0.074	1.045–2.117	0.006
AP	0.372	0.135	0.109–0.161	0.000
ALT	0.001	0.004	−0.015-0.024	0.807
TB	0.018	0.101	−0.010-0.213	0.075
CRP at the end of study
GGT	0.009	0.002	−0.001–0.005	0.217
AP	0.043	0.003	0.001–0.005	0.005
ALT	0.000	0.000	−0.001-0.001	0.847
TB	0.002	0.002	−0.009-0.005	0.581
Leukocytes at the end of study
GGT	0.011	0.053	−0.020-0.126	0.157
AP	0.011	0.611	−0.013-0.075	0.168
ALT	0.006	0.014	−0.013-0.040	0.313
TB	0.026	0.166	0.014–0.318	0.032
Cancer
LT variations	No (n = 60) Mean ± SD		Yes (n = 121) Mean ± SD	p student t-test
GGT	1.48 ± 1.49		2.48 ± 2.76	0.002
AP	0.77 ± 0.97		1.02 ± 1.68	0.283
ALT	0.38 ± 1.42		0.18 ± 0.41	0.293
TB	−0.89 ± 6.69		6.69 ± 4.14	0.815
Infection
LT variations	No (n = 114) Mean ± SD	Beginning PN (n = 17) Mean ± SD	During PN (n = 50) Mean ± SD	p ANOVA
GGT	1.96 ± 2.67	1.76 ± 1.39	2.69 ± 2.14	0.173
AP	0.76 ± 0.93^b	0.71 ± 0.62	1.42 ± 2.36^b	0.025
ALT	0.16 ± 0.40	0.31 ± 0.68	0.42 ± 1.52	0.223
TB	−1.54 ± 4.18	−0.58 ± 3.15	0.18 ± 7.06	0.184
Surgery
LT variations	No (n = 37) Mean ± SD	Beginning PN (n = 132) Mean ± SD	During PN (n = 12) Mean ± SD	P ANOVA
GGT	1.01 ± 1.54^a,b	2.38 ± 2.56^a	3.06 ± 2.60^b	0.004
AP	0.48 ± 0.99^b	0.94 ± 0.99^c	2.34 ± 4.27^b,c	0.001
ALT	0.25 ± 0.44^b	0.25 ± 1.00	0.22 ± 0.48	0.993
TB	−2.26 ± 4.98^b	−0.95 ± 5.19	1.93 ± 3.06^b	0.044

GGT Gamma-glutamyl transferase (μkat/L), AP Alkaline phosphatas (μkat/L) e, ALT Alanine aminotransferase (μkat/L), TB Total bilirubin (μmol/L), SD standard deviation, CRP C-reactive protein, PN parenteral nutrition. R2 determination coefficient B: constant in the statistical model ^a: differences between no condition and condition at the beginning of PN, ^b: differences between no condition and condition during PN treatment, ^c: statistically significant differences between the condition at the beginning of PN and the condition appearing during PN treatment

ISSN: 1476-511X