Table 2 Association between polymorphisms in MEG3/miR-181b and risk of ischemic stroke
From: Association between MEG3/miR-181b polymorphisms and risk of ischemic stroke
Polymorphism | Controls, n = 668 (%) | IS, n = 509 (%) | Crude OR (95% CI) | P value | Adjusted OR(95% CI)†| Adjusted P value†|
|---|---|---|---|---|---|---|
MEG3 rs7158663 | ||||||
 GG | 372 (55.7) | 252 (49.5) | 1.00 |  | 1.00 |  |
 AG | 242 (36.2) | 202 (39.7) | 1.23 (0.96–1.58) | 0.10 | 1.19 (0.92–1.55) | 0.19 |
 AA | 54 (8.1) | 55 (10.8) | 1.50 (1.00–2.26) | 0.05 | 1.49 (0.96–2.32) | 0.08 |
 Dominant model | 296 (44.3) | 257 (50.5) | 1.28 (1.02–1.62) | 0.04 | 1.25 (0.98–1.60) | 0.08 |
 Recessive model | 614 (91.9) | 454 (89.2) | 1.38 (0.93–2.04) | 0.11 | 1.39 (0.91–2.12) | 0.13 |
MEG3 rs4081134 | ||||||
 GG | 392 (58.7) | 310 (60.9) | 1.00 |  | 1.00 |  |
 AG | 230 (34.4) | 167 (32.8) | 0.92 (0.72–1.18) | 0.50 | 0.87 (0.67–1.14) | 0.31 |
 AA | 46 (6.9) | 32 (6.3) | 0.88 (0.55–1.41) | 0.60 | 0.82 (0.49–1.37) | 0.44 |
 Dominant model | 276 (41.3) | 199 (39.1) | 0.91 (0.72–1.15) | 0.44 | 0.86 (0.67–1.11) | 0.25 |
 Recessive model | 622 (93.1) | 477 (93.7) | 0.91 (0.57–1.45) | 0.68 | 0.88 (0.53–1.45) | 0.61 |
miR-181b rs322931 | ||||||
 CC | 473 (70.8) | 315 (61.9) | 1.00 |  | 1.00 |  |
 CT | 179 (26.8) | 170 (33.4) | 1.43 (1.11–1.84) | 0.006 | 1.48 (1.13–1.95) | 0.005 |
 TT | 16 (2.4) | 24 (4.7) | 2.25 (1.18–4.31) | 0.01 | 1.84 (0.91–3.70) | 0.09 |
 Dominant model | 195 (29.2) | 194 (38.1) | 1.49 (1.17–1.91) | 0.001 | 1.52 (1.17–1.97) | 0.002 |
 Recessive model | 652 (97.6) | 485 (95.3) | 2.02 (1.06–3.84) | 0.03 | 1.64 (0.82–3.27) | 0.16 |