Table 5 Combined analyses of polymorphisms in MEG3/miR-181b with IS risk
From: Association between MEG3/miR-181b polymorphisms and risk of ischemic stroke
Combined genotypes | Controls, n = 668 (%) | IS, n = 509 (%) | OR (95% CI) | P value |
|---|---|---|---|---|
MEG3 rs7158663- miR-181b rs322931 | ||||
 rs7158663 GG + rs322931 CC | 267 (40.0) | 154 (30.3) | 1.00 |  |
 rs7158663 GG + rs322931 CT/TT | 105 (15.7) | 98 (19.3) | 1.62 (1.15–2.27) | 0.005 |
 rs7158663 AG/AA + rs322931 CC | 206 (30.8) | 161 (31.6) | 1.36 (1.02–1.80) | 0.04 |
 rs7158663 AG/AA + rs322931 CT/TT | 90 (13.5) | 96 (18.9) | 1.85 (1.30–2.62) | 0.001 |
MEG3 rs4081134- miR-181b rs322931 | ||||
 rs4081134 GG + rs322931 CC | 281 (42.1) | 203 (39.9) | 1.00 |  |
 rs4081134 GG + rs322931 CT/TT | 111 (16.6) | 107 (21.0) | 1.33 (0.97–1.84) | 0.08 |
 rs4081134 AG/AA + rs322931 CC | 192 (28.7) | 112 (22.0) | 0.81 (0.60–1.08) | 0.16 |
 rs4081134 AG/AA + rs322931 CT/TT | 84 (12.6) | 87 (17.1) | 1.43 (1.01–2.03) | 0.04 |