Table 2 Details of metabolic features significantly associated (FDR adjusted P < 0.05) with quantitative variations of HDL cholesterol, and relationships with other phenotypes analyzed in the study cohort. Correlations statistics of metabolic features are given. m/z, mass to charge ratio. rt., retention time. Tchol, Total cholesterol. TGs, Triacylglycerols. Corr, Correlation. Ns, not statistically significant

Negative

[176] [M]-

0.001

1.65 × 10^− 4

0.394

Ns

–

1.85 × 10^− 4

0.392

Ns

–

Negative

[176] [M + 1]-

0.001

1.06 × 10⁻⁴

0.411

Ns

–

1.85 × 10^− 4

0.390

Ns

–

Negative

[176] [M + 2]-

0.001

1.65 × 10⁻⁴

0.404

Ns

–

1.85 × 10^− 4

0.402

Ns

–

Negative

[209] [M]-

1.99 × 10^− 4

0.002

0.311

Ns

–

0.002

0.308

Ns

–

Negative

[209] [M + 1]-

1.90 × 10^− 4

0.002

0.320

0.030

−0.221

0.002

0.310

Ns

–

Negative

[211] [M]-

2.61 × 10⁻⁴

3.07 × 10^− 4

0.380

Ns

–

1.85 × 10^− 4

0.390

Ns

–

Negative

[211] [M + 1]-

2.61 × 10^− 4

2.67 × 10^− 4

0.383

Ns

–

1.85 × 10^− 4

0.393

Ns

–

Negative

[231] [M + 1]-

1.99 × 10^− 4

0.001

0.275

Ns

–

0.001

0.289

Ns

–

Negative

[236] [M]-

3.22 × 10^− 4

5.00 × 10⁻⁵

0.428

Ns

–

4.82 × 10^− 5

0.289

Ns

–

Negative

[236] [M + 1]-

1.99 × 10^− 4

5.00 × 10^− 5

0.440

Ns

–

4.44 × 10^− 5

0.437

Ns

–

Negative

[258] [M]-

2.61 × 10^− 4

1.06 × 10^− 4

0.425

Ns

–

1.85 × 10^− 4

0.394

Ns

–

Negative

[258] [M + 1]-

0.001

1.06 × 10⁻⁴

0.422

Ns

–

1.85 × 10^− 4

0.397

Ns

–

Negative

[260] [M]-

0.001

Ns

–

Ns

–

Ns

–

Ns

–

Negative

[299] [M]-

0.001

Ns

–

0.028

−0.228

Ns

–

Ns

–

Negative

[301] [M]-

2.62 × 10⁻⁴

Ns

–

Ns

–

0.004

0.297

Ns

–

Positive

0.002

Ns

–

1.85 × 10⁻¹⁵

0.721

Ns

–

0.031

0.341

Positive

0.004

Ns

–

2.41 × 10⁻¹²

0.663

Ns

–

0.022

0.347

Positive

[70] [M + 1]+

0.004

Ns

–

1.37 × 10⁻¹⁷

0.757

Ns

–

Ns

–

Positive

[160] [M]+

0.006

1.06 × 10⁻⁴

0.427

Ns

–

2.93 × 10⁻⁴

0.396

Ns

–

Positive

[160] [M + 1]+

0.002

6.45 × 10⁻⁴

0.362

Ns

–

6.49 × 10^− 4

0.362

Ns

–

Positive

[160] [M + 2]+

2.79 × 10⁻⁴

1.65 × 10^− 4

0.392

0.028

−0.247

4.06 × 10^− 4

0.369

Ns

–

Positive

[184] [M + 1]+

0.003

0.001

0.309

Ns

–

5.13 × 10⁻⁴

0.350

Ns

–

Positive

[192] [M]+

0.001

2.43 × 10⁻⁴

0.386

Ns

–

3.04 × 10^− 4

0.375

Ns

–

Positive

[192] [M + 1]+

3.53 × 10⁻⁴

1.06 × 10^− 4

0.417

Ns

–

2.99 × 10^− 4

0.384

Ns

–

Positive

[192] [M + 2]+

0.001

0.008

0.284

Ns

–

0.018

0.258

Ns

–

Positive

[202] [M]+

2.61 × 10⁻⁴

0.002

0.313

0.028

−0.246

0.004

0.286

Ns

–

Positive

[202] [M + 1]+

2.37 × 10⁻⁴

0.002

0.317

0.028

−0.231

0.003

0.293

Ns

–

Positive

[204] [M + 1]+

0.001

2.59 × 10⁻⁴

0.389

Ns

–

7.01 × 10^− 4

0.345

Ns

–

Positive

[226][M + 1]+

0.001

0.001

0.306

Ns

–

0.003

0.291

Ns

–

Positive

[229] [M]+

1.99 × 10⁻⁴

1.06 × 10^− 4

0.387

Ns

–

2.99 × 10^− 4

0.358

Ns

–

Positive

[229][M + 1]+

1.99 × 10⁻⁴

7.58 × 10⁻⁵

0.417

Ns

–

1.71 × 10^− 4

0.400

Ns

–

Positive

[239] [M]+

9.83 × 10⁻⁴

Ns

–

Ns

–

Ns

–

Ns

–

Positive

[257] [M]+

2.61 × 10⁻⁴

0.001

0.345

Ns

–

0.004

0.297

Ns

–

Positive

[257] [M + 1]+

2.61 × 10⁻⁴

0.001

0.353

Ns

–

0.003

0.304

Ns

–