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Table 3 Adjusteda Hazard Ratios (HRs) of Future Stroke between the participants According to quarter of baseline lipid levels

From: Non-traditional lipid profiles associated with ischemic stroke not hemorrhagic stroke in hypertensive patients: results from an 8.4 years follow-up study

Lipid variables

Quarter 1

Quarter 2

Quarter 3

Quarter 4

P trend

TC (mmol/L)

< 4.52

4.52–5.17

5.17–5.84

≥5.84

 

Ischemic stroke (HR,95% CI)

1.00

0.90 (0.64–1.28)

0.93 (0.66–1.32)

1.51 (1.10–2.07)

0.004

Hemorrhagic stroke(HR,95% CI)

1.00

0.63 (0.40–1.00)

1.11 (0.74–1.64)

0.73 (0.47–1.13)

0.492

All stroke (HR,95% CI)

1.00

0.79 (0.60–1.04)

1.02 (0.79–1.32)

1.16 (0.90–1.50)

0.067

TG (mmol/L)

< 0.93

0.93–1.32

1.32–1.98

≥1.98

 

Ischemic stroke (HR,95% CI)

1.00

1.05 (0.74–1.49)

1.57 (1.13–2.18)

1.65 (1.18–2.31)

0.001

Intracerebral Hemorrhage(HR,95% CI)

1.00

1.26 (0.84–1.91)

1.12 (0.72–1.74)

1.24 (0.79–1.94)

0.548

All stroke (HR,95% CI)

1.00

1.11 (0.85–1.45)

1.35 (1.04–1.75)

1.48 (1.13–1.93)

0.003

HDL-C(mmol/L)

< 1.20

1.20–1.40

1.40–1.98

≥1.98

 

Ischemic stroke (HR,95% CI)

1.00

0.91 (0.66–1.27)

1.02 (0.74–1.40)

1.07 (0.78–1.48)

0.496

Intracerebral Hemorrhage(HR,95% CI)

1.00

0.80 (0.52–1.23)

0.91 (0.60–1.37)

0.83 (0.55–1.27)

0.536

All stroke (HR,95% CI)

1.00

0.85 (0.66–1.11)

0.95 (0.74–1.23)

0.95 (0.74–1.23)

0.955

LDL-C(mmol/L)

< 2.29

2.29–2.73

2.73–3.22

≥3.22

 

Ischemic stroke (HR,95% CI)

1.00

0.93 (0.65–1.33)

1.20 (0.85–1.69)

1.89 (1.36–2.61)

< 0.001

Intracerebral Hemorrhage(HR,95% CI)

1.00

1.22 (0.80–1.86)

1.18 (0.77–1.81)

1.96 (0.61–1.52)

0.774

All stroke (HR,95% CI)

1.00

1.04 (0.79–1.37)

1.18 (0.90–1.54)

1.48 (1.14–1.92)

0.001

Non-HDL (mmol/L)

< 3.23

3.23–3.76

3.76–4.29

≥4.29

 

Ischemic stroke (HR,95% CI)

1.00

0.92 (0.65–1.30)

0.99 (0.70–1.39)

1.51 (1.09–2.09)

0.004

Intracerebral Hemorrhage(HR,95% CI)

1.00

0.76 (0.50–1.17)

0.93 (0.62–1.40)

0.68 (0.44–1.07)

0.169

All stroke (HR,95% CI)

1.00

0.85 (0.65–1.11)

0.98 (0.75–1.27)

1.13 (0.88–1.47)

0.167

TC/HDL-C

< 3.52

3.52–3.67

3.67–3.92

≥3.92

 

Ischemic stroke (HR,95% CI)

1.00

1.91 (1.33–2.75)

1.43 (0.98–2.10)

2.02 (1.39–2.92)

0.002

Intracerebral Hemorrhage(HR,95% CI)

1.00

0.49 (0.32–0.75)

0.59 (0.39–0.89)

0.74 (0.49–1.10)

0.334

All stroke (HR,95% CI)

1.00

1.08 (0.83–1.40)

0.94 (0.72–1.23)

1.31 (1.01–1.70)

0.043

LDL/HDL-C

< 1.74

1.74–1.95

1.95–2.18

≥2.18

 

Ischemic stroke (HR,95% CI)

1.00

1.11 (0.76–1.63)

1.85 (1.30–2.64)

2.06 (1.44–2.95)

< 0.001

Intracerebral Hemorrhage(HR,95% CI)

1.00

0.78 (0.52–1.15)

0.60 (0.39–0.92)

0.79 (0.51–1.20)

0.202

All stroke (HR,95% CI)

1.00

0.93 (0.71–1.22)

1.18 (0.90–1.53)

1.41 (1.08–1.84)

0.002

TG/HDL-C

< 0.67

0.67–0.94

0.94–1.44

≥1.44

 

Ischemic stroke (HR,95% CI)

1.00

1.46 (1.05–2.02)

1.24 (0.87–1.76)

1.81 (1.29–2.55)

0.002

Intracerebral Hemorrhage(HR,95% CI)

1.00

1.03 (0.68–1.58)

1.18 (0.78–1.80)

1.22 (0.78–1.90)

0.333

All stroke (HR,95% CI)

1.00

1.27 (0.98–1.65)

1.20 (0.92–1.57)

1.58 (1.21–2.06)

0.002

  1. aIncluded variables: age (years), sex, ethnicity, BMI, current smoking, heavy drinking, diabetes mellitus, SBP, DBP, and anti-hypertension drug treatment
  2. BP blood pressure, BMI body mass index, TC Total cholesterol, TG Triglycerides, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol