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Table 3 Adjusteda Hazard Ratios (HRs) of Future Stroke between the participants According to quarter of baseline lipid levels

From: Non-traditional lipid profiles associated with ischemic stroke not hemorrhagic stroke in hypertensive patients: results from an 8.4 years follow-up study

Lipid variables Quarter 1 Quarter 2 Quarter 3 Quarter 4 P trend
TC (mmol/L) < 4.52 4.52–5.17 5.17–5.84 ≥5.84  
Ischemic stroke (HR,95% CI) 1.00 0.90 (0.64–1.28) 0.93 (0.66–1.32) 1.51 (1.10–2.07) 0.004
Hemorrhagic stroke(HR,95% CI) 1.00 0.63 (0.40–1.00) 1.11 (0.74–1.64) 0.73 (0.47–1.13) 0.492
All stroke (HR,95% CI) 1.00 0.79 (0.60–1.04) 1.02 (0.79–1.32) 1.16 (0.90–1.50) 0.067
TG (mmol/L) < 0.93 0.93–1.32 1.32–1.98 ≥1.98  
Ischemic stroke (HR,95% CI) 1.00 1.05 (0.74–1.49) 1.57 (1.13–2.18) 1.65 (1.18–2.31) 0.001
Intracerebral Hemorrhage(HR,95% CI) 1.00 1.26 (0.84–1.91) 1.12 (0.72–1.74) 1.24 (0.79–1.94) 0.548
All stroke (HR,95% CI) 1.00 1.11 (0.85–1.45) 1.35 (1.04–1.75) 1.48 (1.13–1.93) 0.003
HDL-C(mmol/L) < 1.20 1.20–1.40 1.40–1.98 ≥1.98  
Ischemic stroke (HR,95% CI) 1.00 0.91 (0.66–1.27) 1.02 (0.74–1.40) 1.07 (0.78–1.48) 0.496
Intracerebral Hemorrhage(HR,95% CI) 1.00 0.80 (0.52–1.23) 0.91 (0.60–1.37) 0.83 (0.55–1.27) 0.536
All stroke (HR,95% CI) 1.00 0.85 (0.66–1.11) 0.95 (0.74–1.23) 0.95 (0.74–1.23) 0.955
LDL-C(mmol/L) < 2.29 2.29–2.73 2.73–3.22 ≥3.22  
Ischemic stroke (HR,95% CI) 1.00 0.93 (0.65–1.33) 1.20 (0.85–1.69) 1.89 (1.36–2.61) < 0.001
Intracerebral Hemorrhage(HR,95% CI) 1.00 1.22 (0.80–1.86) 1.18 (0.77–1.81) 1.96 (0.61–1.52) 0.774
All stroke (HR,95% CI) 1.00 1.04 (0.79–1.37) 1.18 (0.90–1.54) 1.48 (1.14–1.92) 0.001
Non-HDL (mmol/L) < 3.23 3.23–3.76 3.76–4.29 ≥4.29  
Ischemic stroke (HR,95% CI) 1.00 0.92 (0.65–1.30) 0.99 (0.70–1.39) 1.51 (1.09–2.09) 0.004
Intracerebral Hemorrhage(HR,95% CI) 1.00 0.76 (0.50–1.17) 0.93 (0.62–1.40) 0.68 (0.44–1.07) 0.169
All stroke (HR,95% CI) 1.00 0.85 (0.65–1.11) 0.98 (0.75–1.27) 1.13 (0.88–1.47) 0.167
TC/HDL-C < 3.52 3.52–3.67 3.67–3.92 ≥3.92  
Ischemic stroke (HR,95% CI) 1.00 1.91 (1.33–2.75) 1.43 (0.98–2.10) 2.02 (1.39–2.92) 0.002
Intracerebral Hemorrhage(HR,95% CI) 1.00 0.49 (0.32–0.75) 0.59 (0.39–0.89) 0.74 (0.49–1.10) 0.334
All stroke (HR,95% CI) 1.00 1.08 (0.83–1.40) 0.94 (0.72–1.23) 1.31 (1.01–1.70) 0.043
LDL/HDL-C < 1.74 1.74–1.95 1.95–2.18 ≥2.18  
Ischemic stroke (HR,95% CI) 1.00 1.11 (0.76–1.63) 1.85 (1.30–2.64) 2.06 (1.44–2.95) < 0.001
Intracerebral Hemorrhage(HR,95% CI) 1.00 0.78 (0.52–1.15) 0.60 (0.39–0.92) 0.79 (0.51–1.20) 0.202
All stroke (HR,95% CI) 1.00 0.93 (0.71–1.22) 1.18 (0.90–1.53) 1.41 (1.08–1.84) 0.002
TG/HDL-C < 0.67 0.67–0.94 0.94–1.44 ≥1.44  
Ischemic stroke (HR,95% CI) 1.00 1.46 (1.05–2.02) 1.24 (0.87–1.76) 1.81 (1.29–2.55) 0.002
Intracerebral Hemorrhage(HR,95% CI) 1.00 1.03 (0.68–1.58) 1.18 (0.78–1.80) 1.22 (0.78–1.90) 0.333
All stroke (HR,95% CI) 1.00 1.27 (0.98–1.65) 1.20 (0.92–1.57) 1.58 (1.21–2.06) 0.002
  1. aIncluded variables: age (years), sex, ethnicity, BMI, current smoking, heavy drinking, diabetes mellitus, SBP, DBP, and anti-hypertension drug treatment
  2. BP blood pressure, BMI body mass index, TC Total cholesterol, TG Triglycerides, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol