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Table 1 Characteristics of the included trials

From: Effects of exercise training on Fetuin-a in obese, type 2 diabetes and cardiovascular disease in adults and elderly: a systematic review and Meta-analysis

Study and design

Sample

Age (years)

Type of exercise

Exercise program characteristics

Reduced Fetuin-A

EPHPP

Lee et al. 2017 [30] Single-group pre-post design

26 men (13 dysglycemic and overweight) without CVD

51.1

Concurrent

Total duration: 12 weeks

Frequency a week: 4 sessions

Duration per session: 60-min

Aerobic; Intensity: NR

Resistance; Intensity: NR

Yes

2

Malin et al. 2013 [28] Single-group pre-post design

13 obese men and women with nonalcoholic fatty liver disease without CVD

50.5

Aerobic

Total duration: 1 week

Frequency a week: 5 sessions

Duration per session: 60-min

Intensity: 85% HRmax

Yes

2

Malin et al. 2014[27] Single-group pre-post design

20 older obese men and women without CVD

66.3

Aerobic

Total duration: 12 weeks

Frequency a week: 7 sessions

Duration per session: 60-min

Intensity: 85% HRmax

Yes

2

Mori et al. 2008[5] Single-group pre-post design

8 men and women with type 2 diabetes mellitus

62.0

Aerobic

Total duration: 12 weeks

Frequency a week: 3–5 sessions

Duration per session: 40-min

Intensity: 103 bpm

No

2

Schultes et al. 2010[39] Single-group pre-post design

14 obese women and without CVD

43.2

Aerobic

Total duration: 6 weeks

Frequency a week: 3 sessions

Duration per session: 60-min

Intensity: 60% VO2peak

No

3

Wilund et al. 2010[40] RCT

17 hemodialysis men and women

59.9

Aerobic

Total duration: 16 weeks

Frequency a week: 3 sessions

Duration per session: 45-min

Intensity: rate of perceived exertion of 12–14

No

4

Winn et al. 2017 [21] Randomized trial without a control group

18 obese men and women without CVD

51.4

Aerobic

Total duration: 4 weeks

Frequency a week: 4 sessions

Duration per session: NR

Intensity: 55% VO2peak or 80% VO2peak

No

5

Yang et al. 2011[29] Single-group pre-post design

40 obese women without CVD

45.3

Concurrent

Total duration: 12 weeks

Frequency a week: 5 sessions

Duration per session: 65-min

Aerobic; Intensity: 60–75% HRmax

Resistance; Intensity: NR

No

2

Zhang et al. 2017 [41] RCT

32 men and women with type 2 diabetes mellitus

47.2

Aerobic

Total duration: 12 weeks

Frequency a week: 5 sessions

Duration per session: 70-min

Aerobic; Intensity: 70% HRmax

Yes

4

  1. Bpm beats per minute, HRmax maximum heart rate.The methodological logical quality of non-randomized controlled trials and studies without control group (N = 8) was assessed using the Quality Assessment Tool for Quantitative Studies of the Effective Public Health Practice Project (EPHPP) (6 evaluation critical methodological components). CVD, cardiovascular disease; RCT, randomised controlled trial