Table 1 Clinical characteristics of enrolled subjects

Age, year

47 (44, 52)

52.5 (49.5, 57)

52.5 (50, 57)

0.964

Sex, male %

47 (69.12)

24 (60.00)

32 (80.00)

0.150

BMI, kg/m²

20.68 (19.90, 21.47)

20.23 (19.35, 21.12)

20.96 (19.92, 21.66)

0.046

Smoking Index

410 (215, 565)

420 (210, 790)

460 (200, 740)

0.645

 SBP, mmHg

112 (102.5, 119)

123 (117, 131)^**

134.5 (124, 154.5)^{**, †}

<0.001

 DBP, mmHg

74 (69, 81)

79.5 (71.5, 84)

80 (75, 90)^*

0.003

 FIB, g/L

2.55 (2.34, 2.91)

2.81 (2.53, 3.07)

3.18 (2.69, 3.67)^**

<0.001

 D-dimer,µg/L

228.210 (120.86, 303.89)

339.20 (224.65, 491.81)^**

333.40 (265.21, 417.22)

<0.001

 cTn, ng/ml

0.03 (0.02, 0.04)

0.02 (0.01, 0.03)

0.05 (0.01, 3.07) †

0.010

 RBG, mmol/L

4.86 (4.42, 5.37)

9.02 (6.58, 12.16)^**

11.51 (8.30, 14.39)^{**, †}

<0.001

 HbA1C, %

4.68 (4.47, 4.94)

5.35 (4.78, 5.86)^**

8.00 (7.27, 9.60)^{**, ††}

<0.001

 LDL-C, mmol/L

2.66 (2.42, 2.89)

3.11 (2.63, 3.92)^**

2.61 (2.15, 3.39)†

<0.001

 TG, mmol/L

1.04 (0.77, 1.34)

1.48 (0.85, 2.37) ^**

1.59 (0.95, 3.40) ^**

<0.001

 TC, mmol/L

3.98 (2.04, 4.76)

4.84 (4.26, 5.42)^**

4.56 (3.26, 6.27)^*

<0.001

 HDL-C, mmol/L

0.70 (0.41, 1.01)

1.04 (0.87, 1.32)^**

0.92 (0.55, 1.19)^†

<0.001

 miR-92a^a

2.39 (1.03)

3.88 (0.78)^**

5.60 (1.22)^**,††

<0.001

Treatment

antiplatelet therapy (90.00%), nitrates (85.71%), ACEI/ARB (72.86%), statins (88.57%), beta-blockers (54.29%), diuretics (62.86%)

antiplatelet therapy (81.20%), nitrates (70.09%), ACEI/ARB (87.18%), statins (95.73%), beta-blockers (29.91%), biguanides (24.79%), insulins (41.88%)