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Fig. 1 | Lipids in Health and Disease

Fig. 1

From: Generation of hyperlipidemic rabbit models using multiple sgRNAs targeted CRISPR/Cas9 gene editing system

Fig. 1

LDL receptor and apoE genes map and targeting sequences. Schematic illustration of the CRISPR/Cas9-targeting sites of rabbit LDLR and apoE genes. Exons are shown as boxes. sgRNA-targeting sequences are highlighted in red, and the protospacer-adjacent motif (PAM) sequences are in green. Four sgRNAs are designed for the LDLR gene (two sgRNAs in exon 2 and two sgRNAs in exon 7) and two sgRNAs are for the apoE gene (one sgRNA targeting the intron and one sgRNA targeting exon 1)

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Lipids in Health and Disease

ISSN: 1476-511X