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Table 5 Mediation tests of the TG levels on the associations between the LIPC genotypes and HDL-C levels in male participants

From: Pleiotropic association of LIPC variants with lipid and urinary 8-hydroxy deoxyguanosine levels in a Taiwanese population

  rs2043085 rs1800588 rs1532085
Criterion 1 α
regression coefficient
Standard error
P value
   
0.059
0.021
0.005
0.063
0.021
0.004
0.061
0.021
0.005
Criterion 2 β
regression coefficient
Standard error
#P value
   
−0.181
0.021
7.2 × 10−16
−0.183
0.021
2.9 × 10−16
− 0.181
0.021
6.5 × 10− 16
γ’
regression coefficient
Standard error
*P value
   
0.022
0.008
0.005
0.026
0.008
0.001
0.022
0.008
0.004
Criterion 3 αβ + γ’
regression coefficient
Standard error
P value
   
0.011
0.008
0.194
0.014
0.009
0.100
0.011
0.009
0.183
Criterion 4 αβ
regression coefficient
Standard error
P value (Sobel test)
   
−0.011
0.004
0.008
−0.012
0.004
0.005
− 0.011
0.004
0.006
  1. LIPC genotypes were analyzed in dominant models,
  2. α: unstandardized coefficient for the association between LIPC genotypes and TG levels
  3. β: unstandardized coefficient for the association between TG and HDL-C levels (when adjusting for LIPC genotypes)
  4. Direct effect = γ’, Total effect = αβ + γ’, Mediation (indirect) effect = αβ
  5. P: adjusted for age, sex, BMI, current smoke; *: indicated the P value of association between SNPs and HDL-C after adjusted for age, sex, BMI, current smoke and TG; #: indicated the P value of association between TG and HDL-C after adjusted for age, sex, BMI, current smoke and SNPs