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Table 5 Mediation tests of the TG levels on the associations between the LIPC genotypes and HDL-C levels in male participants

From: Pleiotropic association of LIPC variants with lipid and urinary 8-hydroxy deoxyguanosine levels in a Taiwanese population

  rs2043085 rs1800588 rs1532085
Criterion 1 α regression coefficient Standard error P value    
0.059 0.021 0.005 0.063 0.021 0.004 0.061 0.021 0.005
Criterion 2 β regression coefficient Standard error #P value    
−0.181 0.021 7.2 × 10−16 −0.183 0.021 2.9 × 10−16 − 0.181 0.021 6.5 × 10− 16
γ’ regression coefficient Standard error *P value    
0.022 0.008 0.005 0.026 0.008 0.001 0.022 0.008 0.004
Criterion 3 αβ + γ’ regression coefficient Standard error P value    
0.011 0.008 0.194 0.014 0.009 0.100 0.011 0.009 0.183
Criterion 4 αβ regression coefficient Standard error P value (Sobel test)    
−0.011 0.004 0.008 −0.012 0.004 0.005 − 0.011 0.004 0.006
  1. LIPC genotypes were analyzed in dominant models,
  2. α: unstandardized coefficient for the association between LIPC genotypes and TG levels
  3. β: unstandardized coefficient for the association between TG and HDL-C levels (when adjusting for LIPC genotypes)
  4. Direct effect = γ’, Total effect = αβ + γ’, Mediation (indirect) effect = αβ
  5. P: adjusted for age, sex, BMI, current smoke; *: indicated the P value of association between SNPs and HDL-C after adjusted for age, sex, BMI, current smoke and TG; #: indicated the P value of association between TG and HDL-C after adjusted for age, sex, BMI, current smoke and SNPs