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Table 2 Effects of Palmitoleic acid in vivo and in vitro clinical trials

From: The impact of sea buckthorn oil fatty acids on human health

Disorder Study Suggested mechanism References
Vaginal inflammatory atrophy Human in vivo study The mechanism is unknown but it reflects a positive increasing trend of the vaginal health index without an increase of circulating estrogen level Erkkola & Yang (2003) [11]
Limo (2004)
Skin hyperpigmentation In vitro study Decrease hyperpigmentation though the Inhibition of tyrosinase, TRP-2 and MITF Yoon (2010) [12]
Wounds infections In vitro study Take part in the growth of C.albicans
decreasing its ability of adhesion in the skin and prevent the attachment of pathogenic yeast cells.
Wille & Kydonieus (2002)
Bacterial infection In vitro study PA calcium salt has a bactericidal effect against S. aureus and P. acnes. Yamamoto (2015) [7]
Hypercholesterolemia Mice in vivo study A possible mechanisms may
be related to the increase of LCAT
Budijanto (1992) [14]
Diabetes and liver dysfunctions Mice in vivo study It stimulate the uptake glucose and impaired the lipogenesis in liver by activation of AMPk and FGF-21, depending on PPAR-α Souza (2016)
Yang & Zhi-Hong (2010)