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Table 5 Effects of γ-linolenic acid in vitro and in vivo clinical trails

From: The impact of sea buckthorn oil fatty acids on human health

Disorder Study Possible mechanism of action References
Acne Human in vivo study Forming products with anti-inflammatory properties through the cyclo-oxygenase and 15-lypogenase. Also, it can improve the hyperproliferative skin condition modulating the protein kinase C. Jung (2014) [8]
Atopic dermatitis Human in vivo study It seems to play na important role as a marker of compliance but not as a therapeutic treatment Jaw (2003)
Yang (2000) [39]
Dry eye Human in vivo study
Rat in vivo study
In combination with omega-3 fatty acids, it decreases the secretion turbidity, the meibomian gland obstruction and edema. Pinna (2007) [40]
Viau (2009) [41]