Fig. 3
From: Apolipoprotein-J blocks increased cell injury elicited by ox-LDL via inhibiting ROS-CaMKII pathway
Effects of ApoJ on CaMKII activation in NRVCs. a. CaMKIIδ expression in NRVCs. Ox-LDL increased CaMKIIδ expression in control infected cells, while ApoJ overexpression decreased it (n = 4/group). b. CaMKII activity in NRVCs. Ox-LDL addition enhanced CaMKII activity, while ApoJ overexpression markedly attenuated it (n = 8/group). c. CaMKII activity in NRVCs. Mn9(III) TBAP inhibited ox-LDL-enhanced CaMKII activity in NRVCs (n = 8/group). d. CaMKII activity in NRVCs. H2O2 addition enhanced CaMKII activity, while ApoJ overexpression markedly attenuated it (n = 8/group). e. CaMKIIδ expression in NRVCs. H2O2 increased CaMKIIδ expression in control adenovirus-infected cells, while ApoJ overexpression decreased it (n = 4/group). *P < 0.05 versus control Ad/PBS group; **P < 0.01 versus control Ad/PBS group, #P < 0.05 versus control Ad/ox-LDL group, ##P < 0.01 versus control Ad/ox-LDL group. #P < 0.05 versus control Ad/ H2O2 group, ##P < 0.01 versus control Ad/ H2O2 group