Table 4 Distribution of lipids profile in different ApoE isoforms and the response to statins
Lipid levels | E2 (n = 164) | E3 (n = 647) | E4 (n = 191) | P value |
|---|---|---|---|---|
before | ||||
TG | 2.14 (1.30–3.00) | 1.83 (1.24–2.48) | 1.81 (1.24–2.68) | 0.031 |
TC | 4.80 (4.31–5.44) | 4.87 (4.22–5.68) | 5.01 (4.27–5.69) | – |
HDL-C | 1.06 (0.92–1.32) | 1.09 (0.94–1.31) | 1.11 (0.94–1.27) | – |
LDL-C | 2.68 (2.29–3.28) | 2.92 (2.40–3.59) | 3.08 (2.43–3.73) | 0.003 |
after | ||||
TG | 1.54 (1.03–2.14) | 1.48 (1.08–1.91) | 1.47 (1.05–2.13) | – |
TC | 3.64 (3.12–4.37) | 3.84 (3.25–4.51) | 4.09 (3.33–4.95) | 0.002 |
HDL-C | 1.11 (0.90–1.32) | 1.08 (0.91–1.29) | 1.08 (0.91–1.27) | – |
LDL-C | 1.89 (1.50–2.35) | 2.08 (1.68–2.68) | 2.25 (1.76–2.87) | < 0.001 |
reduction % | ||||
TG | 25.20 (5.30–41.57) | 21.03(−0.68–35.84) | 16.02(− 4.17–33.33) | 0.021 |
TC | 23.56 (10.73–31.24) | 20.49 (10.70–30.47) | 17.92 (5.20–28.92) | 0.012 |
HDL-C | −4.65(−17.56–10.58) | 0.85(− 13.51–11.94) | 0(−12.94–11.38) | – |
LDL-C | 29.41 (13.47–43.14) | 27.25 (13.53–38.70) | 23.05 (12.47–38.46) | 0.042 |