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Table 2 Baseline characteristics of young patients after a coronary event with or without FH

From: Comparison of long-term outcomes of young patients after a coronary event associated with familial hypercholesterolemia

Variable

Total

FH statusa

 

Probable/Definite

(> 5 points)

Possible

(3–5 points)

None

(< 3 points)

P

Number, n (%)

865 (100)

37 (4.3)

259 (29.9)

569 (65.8)

 

Demographics

 Age, yr

33 (30–34)

31 (28–31)

33 (31–35)

33 (30–34)

0.005

 Female, n(%)

49 (5.7)

2 (5.4)

15 (5.8)

32 (5.6)

0.993

 BMI, kg/m2

27.8 (4.09)

26.5 (4.58)

28.3 (3.82)

27.7 (4.15)

0.057

 Family history of pCAD, n(%)

199 (23.0)

21 (56.8)

178 (68.7)

0 (0.0)

0.000

 Smoking status, n(%)

586 (67.7)

28 (75.7)

177 (68.3)

381 (67.0)

0.531

 Elevated alcohol consumption, n(%)

208 (24.0)

9 (24.3)

55 (21.1)

144 (25.3)

0.445

Past history

 Hypertension, n(%)

318 (36.8)

7 (18.9)

110 (42.5)

201 (35.3)

0.013

 Diabetes mellitus, n(%)

138 (16.0)

2 (5.4)

46 (18.0)

90 (15.7)

0.145

 Pre-existing CAD, n(%)

162 (18.7)

8 (21.6)

45 (17.6)

109 (19.1)

0.792

Lipid profiles

 TC, mmol/L

4.58 (1.46)

8.10 (2.35)

5.02 (1.33)

4.15 (1.00)

0.000

 LDL-C, mmol/L

2.92 (1.24)

6.37 (2.13)

3.30 (1.12)

2.53 (0.71)

0.000

 HDL-C, mmol/L

0.90 (0.20)

0.91 (0.19)

0.91 (0.21)

0.89 (0.20)

0.472

 TG, mmol/L

1.90 (1.29–2.78)

1.56 (1.11–2.55)

2.01 (1.50–2.98)

1.83 (1.27–1.74)

0.017

  1. FH familial hypercholesterolemia, pCAD premature coronary artery disease, BMI body mass index, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, HDL-C low-density lipoprotein cholesterol, TG triglyceride
  2. aBased on Dutch Lipid Clinic Network criteria