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Table 2 General characteristics and genotype distribution

From: Interactions between genetic variants involved in the folate metabolic pathway and serum lipid, homocysteine levels on the risk of recurrent spontaneous abortion

Variable Case (n = 403) Control (n = 342) t/χ 2 p
Ethnic 0.43 0.805
 Han 198 (49.1) 160 (46.8)   
 Zhuang 178 (44.2) 159 (46.5)   
 Minority 27 (6.7) 23 (6.7)   
Education level 1.20 0.550
  ≤ 9 years of school 157 (39.0) 120 (35.1)   
 10–12 years of school 83 (20.6) 74 (21.6)   
  ≥ 13 years of school 163 (40.4) 148 (43.3)   
Gynecological surgery history 1.09 0.298
 Yes 42 (10.4) 28 (8.2)   
 No 361 (89.6) 314 (91.8)   
Current smoking 0.10 0.756
 Yes 7 (1.7) 7 (2.0)   
 No 396 (98.3) 335 (98.0)   
Passive smoking history 0.003 0.960
 Yes 89 (22.1) 75 (21.9)   
 No 314 (77.9) 267 (78.1)   
Drinking history 0.04 0.847
 Yes 43 (10.7) 38 (11.1)   
 No 360 (89.3) 304 (88.9)   
X-ray contact history 0.52 0.596
 Yes 1 (0.2) 2 (0.6)   
 No 402 (99.8) 340 (99.4)   
Chemical exposure history 3.41 0.065
 Yes 1 (0.2) 5 (1.5)   
 No 402 (99.8) 337 (98.5)   
Folic acid supplement 3.91 0.048
 Yes 131 (32.5) 135 (39.5)   
 No 272 (67.5) 207 (60.5)   
Multivitamin supplement 1.38 0.240
 Yes 17 (4.2) 9 (2.6)   
 No 386 (95.8) 333 (97.4)   
Age, year 29.58 ± 5.48 29.88 ± 5.28 0.85 0.673
Folic acid, nmol/L 32.45 ± 8.86 34.35 ± 18.98 −1.79 0.072
Vitamin B12, pg/ml 352.70 ± 124.01 347.48 ± 124.10 0.57 0.567
Homocysteine, umol/L 11.89 ± 4.62 11.20 ± 3.40 2.36 0.018
Total protein, g/L 72.17 ± 6.79 70.67 ± 9.47 2.52 0.012
Total cholesterol, mmol/L 5.43 ± 20.10 4.42 ± 1.91 0.92 0.359
Triglyceride, mmol/L 1.06 ± 0.69 1.03 ± 0.55 0.62 0.536
High-density lipoprotein cholesterol, mmol/L 1.66 ± 0.38 1.73 ± 0.38 −2.38 0.018
Low-density lipoprotein cholesterol, mmol/L 2.61 ± 0.77 2.41 ± 0.68 3.62 < 0.001
Fasting glucose, mmol/L 4.93 ± 0.38 4.92 ± 0.19 0.15 0.884
Fasting insulin, pmol/L 71.13 ± 14.82 67.60 ± 13.84 3.35 0.001
HOMR-IR 2.23 ± 0.45 2.12 ± 0.41 3.48 0.001
IL6, pg/ml 75.12 ± 311.20 40.58 ± 202.95 1.82 0.069
TNFα, pg/ml 28.40 ± 92.16 18.28 ± 31.02 2.08 0.038
MTHFR C677T
 CC 213 (52.9) 253 (74.0) 35.24 < 0.001
 CT 153 (38.0) 78 (22.8) 19.87 < 0.001
 TT 37 (9.2) 11 (3.2) 10.92 0.001
 C allele 579 (71.8) 584 (85.4)
 T allele 227 (28.2) 100 (14.6) 39.62 < 0.001
MTHFR A1298C
 AA 231 (57.3) 221 (64.6) 4.13 0.042
 AC 144 (35.7) 102 (29.8) 2.92 0.088
 CC 28 (6.9) 19 (5.6) 0.61 0.436
 A allele 606 (75.2) 544 (79.5)
 C allele 200 (24.8) 140 (20.5) 3.97 0.046
MTRR A66G
 AA 225 (55.8) 226 (66.1) 8.14 0.004
 AG 148 (36.7) 100 (29.2) 4.67 0.031
 GG 30 (7.4) 16 (4.7) 2.44 0.118
 A allele 598 (74.2) 552 (80.7)
 G allele 208 (25.8) 132 (19.3) 8.90 0.003
  1. HOMA-IR Homeostatic model assessment of insulin resistance, IL6 Interleukin 6, TNFα Tumor necrosis factor α