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Fig. 10 | Lipids in Health and Disease

Fig. 10

From: A therapy with miglustat, 2-hydroxypropyl-ß-cyclodextrin and allopregnanolone restores splenic cholesterol homeostasis in Niemann-pick disease type C1

Fig. 10

Analysis of whole blood (a) of sham-treated Npc1+/+ (n = 3) and Npc1−/− (n = 3) mice. Reference values from the gray backside of “Handbook of Laboratory Animal - Management and Welfare”. Eosinophiles are non-existent in sham-treated Npc1+/+ and Npc1−/−. WBC, RBC, hematocrit, hemoglobin, platelets monocytes, and basophils showed no significant differences in both groups. Sham-treated Npc1−/− demonstated significant changes of neutrophils and lymphoctes, but both results were in the reference values. HPTLC (high performance thin-layer chromatography)-image of blood plasma (b) of sham-treated and treated Npc1+/+ (sham, n = 3; treated, n = 3), and Npc1−/− (sham, n = 3; treated, n = 3) mice. There were no obvious differences in any groups. Data are given as mean ± SEM; two-tailed nonparametic Mann-Whitney-U-Test; p ≤ 0.05 was considered significant (*p ≤ 0.05). RBC: red blood cells, WBC: white blood cells

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