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Fig. 7 | Lipids in Health and Disease

Fig. 7

From: A therapy with miglustat, 2-hydroxypropyl-ß-cyclodextrin and allopregnanolone restores splenic cholesterol homeostasis in Niemann-pick disease type C1

Fig. 7

Transmission electron micrographs of splenic tissue. a, b Lymphocytes (L) and a macrophage (b) of Npc1+/+ mice. c myelin-like inclusions (arrows) in an endothelial cell of a sham-treated Npc1−/− animal. Similar inclusions are seen in a dying sinusoidal cell (arrows, d). e, f congested material (arrows) in a sinusoidal macrophage in a treated Npc1−/− animal. g sinusoidal reticulate cell processes (arrows) in a treated Npc1−/− mouse, without pathologic inclusions. h sinus endothelial cell (En) and subendothelial cell processes (asterisks) of the red pulp without visible signs of pathologic inclusion material. Scale bars: 1 μm (left column); 500 nm (right column)

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