Vitamin D receptor gene polymorphisms affecting changes in visceral fat, waist circumference and lipid profile in breast cancer survivors supplemented with vitamin D3

Table 2 Comparison of changes in response variables before and after vitamin D3 supplementation (4000 IU/day) for 12 weeks

Variables	Before intervention (n = 147)	After intervention (n = 147)	P value*
25(OH)D, nmol/liter	38.1(22.9–62.6)	108.8(73.2–142.0)	< 0.001
BMI, Kg/m2	29.4(27.3–31.9)	29.2(27.3–32.1)	0.57
WC, cm	96.0(91.0–103.7)	98.5(92.2–104.0)	0.20
HC, cm	109.5(105.2–114.0)	107.5(104.0–112.5)	< 0.001
Fat mass (%)	37.15 ± 4.16	37.4 ± 4.14	0.08**
Muscle mass (%)	43.7(41.3–47.3)	43.7(41.0–46.7)	0.42
Trunk fat (%)	33.0(29.3–36.8)	34.0(30.4–37.4)	0.003
Visceral fat level	8.0(7.0–10.0)	8(7.0–10.0)	0.42
LDL, mg/dL	101.8 ± 26.1	98.7 ± 26.5	0.19
HDL, mg/dL	52.0(45.0–59.0)	51(46.0–60.0)	0.86
TC, mg/dL	176.0(157.0–193.5)	167.0(153.5–195.5)	0.17
TG, mg/dL	108.0(80.5–145.0)	108.0(77.5–148.0)	0.92

Values with normal distribution are presented as mean ± SD; values with non-normal distribution are presented as median (Q1, Q3)
*P values were calculated using Wilcoxon signed-rank test
**P values were calculated using the paired sample t-test Wilcoxon test respectively
25(OH)D 25-hydroxy vitamin D, BMI Body mass index, WC Waist circumference, HC Hip circumference, TC Total cholesterol, LDL-C Low-density lipoprotein cholesterol, HDL-C High-density lipoprotein cholesterol, TG Triglycerides

ISSN: 1476-511X