U-shaped association between low-density lipid cholesterol and diabetes mellitus in patients with hypertension

Table 3 Logistic OR (95% CIs) for diabetes mellitus and LDL-C stratified by quartile

	case/total	model1		model2		model3
		OR(95%CIs)	p-value	OR(95%CIs)	p-value	OR(95%CIs)	p-value
LDL-C < 3.4 mmol/L,n = 5038
Q1	337/1260	1.425(1.192,1.702)	< 0.001	1.441(1.205,1.723)	< 0.001	1.248(1.026,1.517)	0.027
Q2	332/1259	1.195(0.997,1.433)	0.054	1.194(0.996,1.432)	0.056	1.146(0.944,1.391)	0.168
Q3	298/1257	1.037(0.862,1.247)	0.701	1.026(0.853,1.235)	0.784	1.031(0.848,1.253)	0.761
Q4	291/1262	ref		ref		ref
P for trend		< 0.001		< 0.001		0.015
3.4 mmol/L ≤ LDL-C < 4.1 mmol/L,n = 2847
Q1	171/712	ref		ref		ref
Q2	142/712	0.795(0.618,1.022)	0.074	0.814(0.632,1.049)	0.112	0.806(0.618,1.051)	0.111
Q3	154/712	0.880(0.687,1.128)	0.313	0.899(0.700,1.153)	0.401	0.936(0.721,1.215)	0.619
Q4	131/711	0.708(0.548,0.915)	0.008	0.735(0.568,0.951)	0.019	0.753(0.575,0.986)	0.039
P for trend		0.023		0.047		0.105
LDLC ≥4.1 mmol/L,n = 2007
Q1	103/502	ref		ref		ref
Q2	103/502	1.012(0.746,1.374)	0.938	1.043(0.766,1.42)	0.789	0.999(0.721,1.383)	0.994
Q3	102/501	0.990(0.729,1.346)	0.950	1.005(0.737,1.37)	0.975	0.990(0.715,1.371)	0.951
Q4	135/502	1.425(1.063,1.910)	0.018	1.489(1.108,2.003)	0.008	1.536(1.126,2.096)	0.007
P for trend		0.024		0.013		0.008

model1, unadjusted;
model2, adjusted for age, sex;
model3, adjusted for age, sex, smoking, alcohol consumption, history of CAD, stroke, consumption of β -blockers, calcium channel blockers, ACEI/ARB, statin, BMI, SBP, DBP, TG, HDL-C and eGFR;
OR, odds ratio, CIs, confidence Intervals

ISSN: 1476-511X