Fig. 4

Molecular interactions involved in the apo(a)-mediated activation of collagen-primed monocytes. a, b Monocytes were incubated at 37 °C on albumin (open bar), or type I collagen (closed bars) with 100 nM 10 K apo(a) and/or 100 mM AHA, or 100 nM plasminogen (Plg) and/or 10 μM amiloride. c Monocytes were first preincubated for 1 h at 37 °C with 200 μg/ml carboxypeptidase B (CpB) before being incubated with or without 100 nM 10 K apo(a). Results (means ± standard deviations) are expressed as ratios to the ROS production (a) or MMP-9 secretion (b) on albumin-coated plates. a.u.: arbitrary units, NS: non-significant, *: p < 0.05, **: p < 0.01