Sequence analysis and variant identification at the APOC3 gene locus indicates association of rs5218 with BMI in a sample of Kuwaiti’s

Table 4 Association of the 4 APOC3 SNPs with lipid profiles in the Kuwaiti Cohort (n = 733)

SNP	Parameters		GG		GC		CC	p-value
		n		n		n
rs5128	BMI	349	26.77 ± 0.33	131	28.03 ± 0.65	39	27.71 ± 1.05	0.08
	TC	348	4.663 ± 0.511	131	4.72 ± 0.08	39	4.58 ± 0.14	0.73
	TG	394	0.90 ± 0.04	131	1.00 ± 0.05	39	1.10 ± 0.15	0.05
	VLDL	344	0.38 ± 0.02	129	0.41 ± 0.02	38	0.48 ± 0.07	0.06
	HDL	337	1.18 ± 0.02	127	1.21 ± 0.04	36	1.19 ± 0.05	0.55
	LDL	337	3.08 ± 0.04	127	3.08 ± 0.07	36	2.92 ± 0.12	0.44
rs2070668	BMI	179	27.32 ± 0.48	251	27.32 ± 0.44	89	26.41 ± 0.61	0.42
	TC	179	4.67 ± 0.07	251	4.69 ± 0.062	88	4.64 ± 0.094	0.95
	TG	179	0.96 ± 0.06	251	0.94 ± 0.05	89	0.86 ± 0.05	0.84
	VLDL	174	0.41 ± 0.03	249	0.40 ± 0.02	88	0.36 ± 0.02	0.89
	HDL	174	1.19 ± 0.02	241	1.19 ± 0.02	85	0.17 ± 0.03	0.27
	LDL	174	3.04 ± 0.06	241	3.09 ± 0.05	85	3.07 ± 0.09	0.72
rs2854117	BMI	211	26.77 ± 0.42	235	27.38 ± 0.46	73	27.57 ± 0.74	0.50
	TC	210	4.63 ± 0.06	235	4.67 ± 0.06	73	4.79 ± 0.10	0.55
	TG	211	0.91 ± 0.05	235	0.90 ± 0.04	73	1.08 ± 0.11	0.21
	VLDL	207	0.39 ± 0.02	231	0.38 ± 0.02	73	0.46 ± 0.05	0.21
	HDL	202	1.17 ± 0.02	229	1.21 ± 0.02	69	0.18 ± 0.04	0.12
	LDL	202	3.06 ± 0.05	229	3.05 ± 0.05	69	3.14 ± 0.09	0.66
KUAPOC3N3	BMI	514	27.12 ± 0.29	5	31.59 ± 3.34	–	–	0.14
	TC	513	4.68 ± 0.04	5	4.16 ± 0.23	–	–	0.10
	TG	514	0.93 ± 0.03	5	0.80 ± 0.24	–	–	0.12
	VLDL	506	0.34 ± 0.01	5	0.36 ± 0.11	–	–	0.14
	HDL	495	1.19 ± 0.02	5	1.02 ± 0.09	–	–	0.60
	LDL	495	3.07 ± 0.04	5	2.79 ± 0.19	–	–	0.35

SNP Single nucleotide polymorphism, BMI Body mass index, TC Total cholesterol, TG Triglycerides, VLDL Very low-density lipoprotein, HDL High density lipoprotein, LDL Low density lipoprotein, mmol/L millimoles per liter

ISSN: 1476-511X