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Table 1 Baseline characteristics of elderly AMI patients

From: Neutrophil to high-density lipoprotein ratio has a superior prognostic value in elderly patients with acute myocardial infarction: a comparison study

Variable

NHR < 5.74

NHR ≥ 5.74

P

MHR < 0.67

MHR ≥ 0.67

P

LDL-C/HDL-C < 3.57

LDL-C/HDL-C ≥ 3.57

P

n = 249

n = 279

n = 367

n = 161

n = 439

n = 89

Age, year

72.54 ± 0.34

72.76 ± 0.32

0.555

72.35 ± 0.27

73.36 ± 0.42

0.048

72.60 ± 0.25

72.93 ± 0.56

0.754

Gender (male), n (%)

150 (60.24%)

183 (65.59%)

0.203

206 (56.13%)

127 (78.89%)

< 0.001

271 (61.73%)

62 (69.66%)

0.157

Smoking status, n (%)

92 (36.95%)

118 (42.29%)

0.210

134 (36.51%)

76 (47.20%)

0.021

167 (38.04%)

43 (48.31%)

0.071

Hypertension, n (%)

144 (57.83%)

169 (60.57%)

0.522

215 (58.58%)

98 (60.87%)

0.623

267 (60.82%)

46 (51.69%)

0.110

Prior CAD, n (%)

40 (16.06%)

30 (10.75%)

0.072

50 (13.62%)

20 (12.42%)

0.708

60 (13.67%)

10 (11.24%)

0.537

Diabetes, n (%)

51 (20.48%)

86 (30.82%)

0.007

94 (25.61%)

43 (26.71%)

0.792

112 (25.51%)

25 (28.09%)

0.613

CVD, n (%)

33 (13.25%)

39 (13.98%)

0.808

51 (13.90%)

21 (13.04%)

0.793

59 (13.44%)

13 (14.61%)

0.770

SBP on admission (mmHg)

132.81 ± 1.50

128.10 ± 1.49

0.013

131.50 ± 1.31

127.65 ± 1.77

0.073

130.14 ± 1.15

131.25 ± 2.75

0.854

DBP on admission (mmHg)

75.65 ± 0.84

75.61 ± 0.94

0.927

76.31 ± 0.76

74.07 ± 1.14

0.042

75.69 ± 0.69

75.34 ± 1.63

0.733

HR on admission (beats/min)

74.56 ± 0.93

80.35 ± 0.96

< 0.001

76.44 ± 0.80

80.31 ± 1.29

0.023

77.11 ± 0.74

80.13 ± 1.78

0.364

Hospitalization day

7.56 ± 0.36

8.99 ± 0.45

0.013

7.99 ± 0.31

9.06 ± 0.66

0.466

8.08 ± 0.31

9.47 ± 0.85

0.290

Diagnosis, n (%)

 STEMI

98 (39.36%)

170 (60.93%)

< 0.001

181 (49.32%)

87 (54.04%)

0.318

216 (49.20%)

52 (58.43%)

0.112

 NSTEMI

151 (60.64%)

109 (39.07%)

< 0.001

186 (50.68%)

74 (45.96%)

0.318

223 (50.80%)

37 (41.57%)

0.112

 Killip class, III-IV, n (%)

41 (16.47%)

60 (21.51%)

0.142

61 (16.62%)

40 (24.84%)

0.027

81 (18.45%)

20 (22.47%)

0.379

 LVEF, %

53.72 ± 0.78

50.45 ± 0.75

0.001

52.85 ± 0.61

50.02 ± 1.11

0.042

51.93 ± 0.61

52.27 ± 1.23

0.464

 Creatinine (μmol/L)

84.54 ± 1.70

95.13 ± 2.13

< 0.001

87.59 ± 1.71

95.94 ± 2.34

< 0.001

88.89 ± 1.47

96.29 ± 4.01

0.169

 AST (u/L)

56.61 ± 4.44

119.89 ± 7.63

< 0.001

92.17 ± 6.09

85.22 ± 7.04

0.373

89.69 ± 4.97

91.84 ± 13.88

0.584

 ALT (u/L)

29.47 ± 1.72

43.56 ± 2.76

< 0.001

34.27 ± 1.72

42.94 ± 3.91

0.004

36.85 ± 1.94

37.22 ± 3.15

0.904

 NT-proBNP (pg/mL)

4815.92 ± 560.61

5601.26 ± 538.24

0.057

4934.39 ± 467.27

5906.79 ± 697.26

0.008

5204.51 ± 431.33

5316.10 ± 888.55

0.287

 CTnI (pg/mL)

9435.84 ± 911.21

20,906.32 ± 1202.02

< 0.001

14,994.50 ± 975.91

16,642.27 ± 1426.50

0.094

15,550.19 ± 880.71

15,234.31 ± 2005.53

0.918

 HDL-C (mmol/L)

1.30 ± 0.04

0.98 ± 0.02

< 0.001

1.24 ± 0.03

0.89 ± 0.02

< 0.001

1.19 ± 0.02

0.84 ± 0.02

< 0.001

 LDL-C (mmol/L)

2.55 ± 0.06

2.66 ± 0.06

0.312

2.69 ± 0.05

2.43 ± 0.07

0.004

2.41 ± 0.04

3.62 ± 0.10

< 0.001

 Total triglyceride (mmol/L)

1.36 ± 0.07

1.42 ± 0.07

0.113

1.33 ± 0.06

1.53 ± 0.10

0.012

1.36 ± 0.06

1.55 ± 0.09

0.002

 Total cholesterol (mmol/L)

4.10 ± 0.07

4.14 ± 0.07

0.693

4.25 ± 0.06

3.84 ± 0.08

< 0.001

3.95 ± 0.05

4.98 ± 0.12

< 0.001

 WBC count (109/L)

6.72 ± 0.13

11.10 ± 0.21

< 0.001

8.30 ± 0.17

10.72 ± 0.31

< 0.001

8.97 ± 0.17

9.38 ± 0.38

0.780

 Platelet count (109/L)

191.70 ± 3.82

212.31 ± 4.01

< 0.001

200.59 ± 3.32

207.16 ± 5.27

0.379

200.23 ± 3.06

214.22 ± 7.08

0.372

 Neutrophil count (109/L)

4.56 ± 0.11

9.19 ± 0.21

< 0.001

6.36 ± 0.17

8.47 ± 0.33

< 0.001

6.98 ± 0.18

7.14 ± 0.37

0.357

 Lymphocyte count (109/L)

1.40 ± 0.04

1.37 ± 0.04

0.142

1.32 ± 0.03

1.53 ± 0.06

0.002

1.37 ± 0.03

1.47 ± 0.08

0.809

 Monocyte count (109/L)

0.45 ± 0.01

0.65 ± 0.02

< 0.001

0.43 ± 0.01

0.84 ± 0.02

< 0.001

0.55 ± 0.01

0.57 ± 0.03

0.145

 Hemoglobin (mg/dL)

126.65 ± 1.19

125.87 ± 1.10

0.536

126.88 ± 0.95

124.78 ± 1.53

0.297

126.02 ± 0.86

127.34 ± 2.26

0.922

Medications in hospital, n (%)

 Antiplatelet therapy

243 (97.59%)

271 (97.13%)

0.744

361 (98.37%)

153 (95.03%)

0.051

427 (97.27%)

87 (97.75%)

0.003

 Beta-blocker

182 (73.09%)

198 (70.97%)

0.587

271 (73.84%)

109 (67.70%)

< 0.001

317 (72.21%)

63 (70.79%)

0.237

 ACEI/ARB

191 (76.71%)

187 (67.03%)

0.014

271 (73.84%)

107 (66.46%)

0.083

318 (72.44%)

60 (67.42%)

0.596

 Statin

247 (99.20%)

275 (98.57%)

0.915

364 (99.18%)

158 (98.14%)

0.297

434 (98.86%)

88 (98.88%)

0.002

Long-term clinical events, n (%)

 Long-term mortality

17 (6.83%)

59 (21.15%)

< 0.001

40 (10.90%)

36 (22.36%)

0.001

50 (11.39%)

26 (29.21%)

< 0.001

 Long-term RMI

10 (4.02%)

31 (11.11%)

0.002

22 (5.99%)

19 (11.80%)

0.022

29 (6.61%)

12 (13.48%)

0.010

  1. AMI acute myocardial infarction, NHR neutrophil to high-density lipoprotein cholesterol ratio, MHR monocyte to high-density lipoprotein cholesterol ratio, LDL-C/HDL-C low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio, CAD coronary artery disease, CVD cerebrovascular diseases, SBP systolic blood pressure, DBP diastolic blood pressure, HR heart rate, STEMI ST-segment elevation myocardial infarction, NSTEMI non-ST-elevation myocardial infarction, LVEF left ventricular ejection fraction, AST aspartate aminotransferase, ALT alanine aminotransferase, NT-proBNP N-terminal pro-brain natriuretic peptide, CTnI cardiac troponin I, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, WBC white blood cell, ACEI/ARB angiotensin-converting enzyme inhibitor/ angiotensin II receptor blocker, RMI recurrent myocardial infarction
  2. Data presented are mean ± SEM or n(%)
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Lipids in Health and Disease

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