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Table 1 Filtering of the studies found according to the predetermined selection criteria. Left: List of articles found by the search. Top: the specified inclusiocriteria, based on which the analysis of the articles took place. Legend: x = criterion applies, o = criterion does not apply, bold font = these studies were included in the literature review, italic font = these articles have been excluded from the literature review

From: What is the impact of the adjunctive use of omega-3 fatty acids in the treatment of periodontitis? A systematic review and meta-analysis

Studies

Clinical Trial

RCT

Human

Periodontitis

Adjunctive ω3-FS

Adjunctive aspirin

Non-surgical periodontal therapy

Surgical periodontal therapy

Placebo control

Probing depth

Clinical attachment level

Gingiva index

Bleeding on probing

Plaque index

CRP

Elwakeel et al. 2015 [29]

x

x

x

x

x

x

x

o

x

x

x

x

o

x

o

Naqvi et al. 2014 [22]

x

x

x

x

x

x

o

o

x

x

o

x

x

x

x

Deore et al. 2014 [30]

x

x

x

x

x

o

x

o

x

x

x

x

x

o

x

Martinez et al. 2014 [31]

x

x

x

x

x

o

x

o

x

x

x

o

x

x

o

Elkhouli 2011 [13]

x

x

x

x

x

x

x

x

x

x

x

x

x

x

o

El-Sharkawy et al. 2010 [15]

x

x

x

x

x

x

x

o

x

x

x

x

x

x

o

Rosenstein et al. 2003 [24]

x

x

x

x

x

o

o

o

x

x

o

x

o

x

o

Campan et al. 1997[33]

x

x

x

o

o

o

o

o

x

o

o

x

o

x

o

Campan et al.1996 [26]

x

x

x

o

o

o

o

o

x

o

o

x

o

x

o

Jenabian et al. 2012[25]

x

x

x

o

x

o

o

o

x

o

o

x

x

o

o

Naqvi et al. 201 7 [23]

x

x

x

x

x

x

o

o

x

x

x

x

x

x

o

Lourenço et al. 2018 [21]

x

x

o

x

x

o

o

o

x

x

o

x

o

x

x

Rampally et al. 2019 [27]

x

x

x

x

x

x

x

o

x

x

x

x

o

x

o

Keskiner et al.2017 [32]

x

x

x

x

x

o

x

0

x

x

x

x

x

x

o