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Table 2 Comparison of study design: Left: Study parameters considered. Top: Included studies. Yes / no: criterion fulfilled / not met

From: What is the impact of the adjunctive use of omega-3 fatty acids in the treatment of periodontitis? A systematic review and meta-analysis

 Elwakeel und Hazaa (2015) [29]Deore et al. (2014) [30]Elkhouli (2011) [13]El-Sharkawy et al. (2010) [15]Martinez et al. (2014) [31]Keskiner et al. (2017) [32]
Clinical trialYesYesYesYesYesYes
Randomised, controlledYesYesYesYesYesYes
Chronic periodontitis (CP)moderate-severe CP + diabetes type2moderate-severe CPmoderate-severe periodontitis +at least 1 furcation degree 2severe CPlight, moderate, severe CPYes
SmokerNoNoYes (< 10/day)NoYesNo
Omega3-fatty acids dosage1000 mg, 3x/ day for 6 months300 mg(180 mg EPA, 120 mg DHA), 1x/day for 12 weeks1000 mg (300 mg DHA+
150 mg EPA) 3x/day for 6 months
900 mg EPA, 900 mg DHA, wheat germ oil300 mg (each 180 mg EPA+
120 mg DHA)
for 12 months
6.25 mg EPA, 19.19 mg DHA 2x/day for 6 months
Aspirin75 mg, 1x/day for 6 months only test groupNo75 mg 1x /day für 6 months81 mg 1x /dayNoNo
PlaceboCoconut oil for omega-3, lactose for aspirin300 mg paraffin / dayYesYesYesYes
Number of patients40 (20/20)60 (30/30)40 (20/20)80 (40/40)15 (test 7/control 8)30 (15/15)
Number of examiners111at least 2 calibrated> 1 exact specification is missing,calibrated1
Study period6 months3 months6 months6 months12 months6 months
Oral hygiene instructionsYesYesYesYesNoYes
Subgingival instrumentationYesYesYesYesYesYes
Clinical periodontal parameter OHIS    
BOPNoNo (only at baseline)Gingival bleeding indexYesYesYes
Recording of the parameters0, 3, 6 months0, 1.5, 3 months0, 3, 6 months0, 3, 6 months0,4,12 months0,1,3,6 months