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Table 3 Differences in LDL-C between the 3 methods based on pretreatment LDL-CF quartiles

From: Achieving low-density lipoprotein cholesterol targets as assessed by different methods in patients with familial hypercholesterolemia: an analysis from the HELLAS-FH registry

  LDL-CF Quartile min-max Pre-treatment (mg/dL)
dLDLF-M/H dLDLF-Lp(a)corM/H
Adults 1st (132–196 mg/dL) 0.5 (−2.7–2.1) 2.2 (1.6–3.6)
2nd (196–220 mg/dL) 1.6 (−0.7–2.5)* 6.5 (4.0–15.5)*
3rd (220–258 mg/dL) 1.6 (−0.7–2.6)* 11.3 (5.9–19.2)*
4th (258–680 mg/dL) 2.1 (0.0–3.0)* 9.9 (4.8–22.1)*
Children 1st (100–193 mg/dL) 2.6 (1.8–3.8) 3.8 (2.0–18.2)
2nd (198–219 mg/dL) 3.9 (3.3–4.7)* 10.4 (5.8–24.6)*
3rd (221–257 mg/dL) 3.8 (3.0–5.0)* 7.8 (5.5–9.7)*
4th (258–594 mg/dL) 3.1 (2.6–3.8)* 8.3 (5.4–17.8)*
  1. Values are presented as median (interquartile range)
  2. LDL-CF Low-density lipoprotein cholesterol as calculated by the Friedewald formula, LDL-CM/H Low-density lipoprotein cholesterol as calculated by the Marin/Hopkins formula, LDL-CLp(a)corM/H Corrected for Lp(a) levels low-density lipoprotein cholesterol as calculated by the Marin/Hopkins formula, dLDLF-M/H: LDL-CF - LDL-CMH, dLDLF-Lp(a)corM/H: LDL-CF - LDLLp(a)corM/H
  3. *P < 0.05 for the difference between LDL-C formulas in each quartile