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Table 4 Lipid profile of adult patients on lipid-lowering treatment

From: Achieving low-density lipoprotein cholesterol targets as assessed by different methods in patients with familial hypercholesterolemia: an analysis from the HELLAS-FH registry

Parameter

Adults

Statin ± Ezetimibe

(n = 891)

Statin ± Ezetimibe + PCSK9i

(n = 59)

Pre-treatment

Post-treatment

Pre-treatment

Post-treatment

Total cholesterol, mg/dL

(mmol/L)

326 ± 79

(8.4 ± 2.0)

225 ± 63††

(5.8 ± 1.6)††

392 ± 123

(10.1 ± 3.2)

215 ± 109††

(5.6 ± 2.8)

Triglycerides, mg/dL

(mmol/L)

128 (94–179)

[1.4 (1.4–2.0)]

110 (80–154)††

[1.2 (0.9–1.7)]††

140 (99–192)

[1.6 (1.1–2.2)]

108 (75–153)††

[1.2 (0.8–1.7)]††

HDL-C, mg/dL

(mmol/L)

51 ± 14

(1.3 ± 0.4)

51 ± 15

(1.3 ± 0.4)

51 ± 13

(1.3 ± 0.3)

50 ± 14

(1.3 ± 0.3)

non-HDL-C, mg/dL

(mmol/L)

275 ± 79

(7.1 ± 2.0)

174 ± 63††

(4.5 ± 1.6)††

342 ± 119

(8.8 ± 3.1)

164 ± 106††

(4.2 ± 2.7)††

LDL-CF, mg/dL

(mmol/L)

244 ± 68

(6.3 ± 1.8)

149 ± 59††

(3.9 ± 1.5)††

311 ± 118

(8.0 ± 3.1)

141 ± 103††

(3.6 ± 2.7)††

LDL-CM/H, mg/dL

(mmol/L)

244 ± 68

(6.3 ± 1.8)

150 ± 59††

(3.9 ± 1.5)††

311 ± 118

(8.0 ± 3.1)

141 ± 102††

(3.6 ± 2.6)††

aLDL-CLp(a)corM/H, mg/dL

(mmol/L)

243 ± 77

(6.3 ± 2.0)

118 ± 52†,§,††

(3.1–1.3)†,§,††

-b

-b

aLp(a), mg/dL

(nmol/L)

25 (10–68)

[50.7 (18.0–144)]

26 (10–68)

[52.9 (18.0–144)]

-b

-b

  1. Data are presented as mean ± standard deviation or median (interquartile range) for parametric and non-parametric variables, respectively
  2. HDL-C High-density lipoprotein cholesterol, LDL-CF Low-density lipoprotein cholesterol as calculated by the Friedewald formula, LDL-CM/H Low-density lipoprotein cholesterol as calculated by the Marin/Hopkins formula, LDL-CLp(a)corM/H Corrected for Lp(a) levels low-density lipoprotein cholesterol as calculated by the Marin/Hopkins formula, PCKS9i Proprotein convertase subtilisin/kexin type 9 inhibitor, Lp(a) was converted using the formula: Lp(a) nmol/L = 2.18 × Lp(a) mg/dL − 3.83
  3. P < 0.001 vs LDL-CF and LDL-CM/H, §P < 0.001 for the comparison of LDL-C change compared with the change of LDL-CF and LDL-CM/H,††P < 0.001 vs pre-treatment
  4. a: Data available for 342 patients
  5. b: Data for Lp(a) levels in adult patients treated with PCSK9i were available only for 5 patients and thus were not included in the analysis