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Table 4 Meta-analysis of the ADRB3 Trp64Arg polymorphism with plasma lipid levels after excluding the study with heterogeneity

From: The Trp64Arg polymorphism in β3 adrenergic receptor (ADRB3) gene is associated with adipokines and plasma lipids: a systematic review, meta-analysis, and meta-regression

Groups or subgroups Comparisons (Subjects) SMD (95% CI) PHeterogeneity PSMD
TG
 All 146 (38,535) 0.04 (0.01–0.06) 0.07 < 0.01
 Studies in HWE 130 (34,679) 0.02 (0.00–0.05) 0.24 0.05
 Caucasian 42 (14,786) 0.04 (−0.01–0.09) 0.37 0.08
 Asian 92 (21,766) 0.04 (0.01–0.07) 0.05 0.01
 Chilean 2 (234) −0.18 (− 0.47–0.10) 0.79 0.21
 Brazilian 2 (223) 0.22 (−0.13–0.57) 0.37 0.22
 Indonesian 4 (531) −0.18 (− 0.45–0.09) 0.84 0.20
 Other ethnic 4 (995) −0.05 (− 0.19–0.09) 0.28 0.51
 Female 38 (10,163) 0.05 (0.00–0.10) 0.05 0.05
 Male 26 (7602) 0.01 (−0.05–0.06) 0.30 0.83
 Obesity 37 (5290) 0.09 (0.02–0.16) 0.49 0.01
 T2DM 17 (3592) 0.13 (0.05–0.21) 0.42 < 0.01
 Hypertension 4 (781) −0.05 (− 0.22–0.13) 0.28 0.61
 CAD 7 (1225) − 0.12 (− 0.25–0.01) 0.46 0.07
 Healthy 62 (22,922) 0.02 (−0.02–0.05) 0.08 0.35
 Children 11 (2025) 0.08 (−0.01–0.18) 0.68 0.08
TC
 All 153 (46,775) 003 (0.01–0.05) 0.11 < 0.01
 Studies in HWE 133 (41,641) 0.03 (0.01–0.06) 0.17 0.01
 Caucasian 42 (17,507) 0.04 (−0.01–0.08) 0.43 0.11
 Asian 99 (26,340) 0.03 (0.01–0.06) 0.20 0.01
 Chilean 3 (340) 0.04 (−0.19–0.27) 0.83 0.73
 Brazilian 4 (1310) 0.09 (−0.06–0.24) 0.52 0.23
 Other ethnic 5 (1278) 0.00 (−0.27–0.27) < 0.01 0.98
 Female 36 (11,377) 0.05 (0.00–0.10) 0.76 0.04
 Male 25 (7681) −0.01 (− 0.06–0.05) 0.34 0.81
 Obesity 35 (5269) 0.08 (0.00–0.15) 0.70 0.04
 T2DM 20 (5257) 0.04 (−0.02–0.11) 0.75 0.22
 Hypertension 6 (1182) 0.04 (−0.10–0.18) 0.57 0.54
 CAD 7 (1225) −0.13 (− 0.26–0.00) 0.28 0.06
 Healthy 62 (25,355) 0.03 (−0.00–0.06) 0.13 0.07
 Children 12 (2039) 0.04 (−0.05–0.14) 0.39 0.36
LDL-C
 All 93 (22,397) 0.02 (−0.01–0.05) 0.54 0.16
 Studies in HWE 81 (19,151) 0.02 (−0.02–0.05) 0.49 0.38
 Caucasian 27 (7116) −0.01 (− 0.08–0.06) 0.49 0.84
 Asian 58 (12,539) 0.04 (0.00–0.08) 0.52 0.04
 Brazilian 3 (1238) −0.03 (− 0.19–0.12) 0.20 0.67
 Other ethnic 4 (1138) −0.07 (− 0.20–0.06) 0.85 0.31
 Female 23 (5740) 0.04 (−0.03–0.10) 0.66 0.29
 Male 17 (2512) 0.01 (−0.08–0.10) 0.12 0.84
 Obesity 29 (4688) 0.02 (−0.05–0.09) 0.57 0.55
 T2DM 8 (1890) 0.03 (−0.08–0.14) 0.44 0.62
 CAD 6 (1040) −0.05 (− 0.18–0.09) 0.87 0.51
 Healthy 34 (9862) 0.05 (−0.00–0.09) 0.22 0.07
 Children 8 (1768) 0.10 (−0.00–0.20) 0.42 0.06
HDL-C
 All 150 (43,951) −0.04 (− 0.06--0.02) 0.55 0.01
 Studies in HWE 134 (39,781) −0.03 (− 0.06--0.01) 0.22 0.01
 Caucasian 45 (17,720) −0.04 (− 0.09–0.00) 0.60 0.06
 Asian 90 (23,675) −0.03 (− 0.06--0.01) 0.05 0.02
 Chilean 3 (340) −0.10 (− 0.33–0.13) 0.37 0.38
 Brazilian 3 (295) 0.21 (−0.09–0.50) 0.42 0.17
 Indonesian 4 (531) −0.07 (− 0.34–0.20) 0.52 0.59
 Other ethnic 3 (483) −0.23 (− 042--0.04) 0.55 0.02
 Female 38 (11,946) −0.05 (− 0.10--0.00) 0.73 0.03
 Male 27 (8774) −0.02 (− 0.07–0.03) 0.13 0.50
 Obesity 33 (5017) −0.05 (− 0.10--0.00) 0.17 0.05
T2DM 15 (1923) −0.15 (− 0.25--0.05) 0.68 < 0.01
 Hypertension 4 (957) 0.01 (−0.15–0.16) 0.10 0.91
 CAD 7 (1403) −0.07 (− 0.19–0.06) 0.09 0.31
 Healthy 67 (24,960) −0.02 (− 0.05–0.01) 0.49 0.21
 Children 14 (2279) −0.07 (− 0.15–0.02) 0.33 0.15
  1. ADRB3 beta3-adrenergic receptor gene, SMD standardized mean difference, 95% CI 95% confidence interval, HWE Hardy-Weinberg equilibrium, TG triglycerides, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, CAD coronary artery disease, T2DM type 2 diabetes mellitus