Table 4 Meta-analysis of the ADRB3 Trp64Arg polymorphism with plasma lipid levels after excluding the study with heterogeneity
Groups or subgroups | Comparisons (Subjects) | SMD (95% CI) | PHeterogeneity | PSMD |
|---|---|---|---|---|
TG | ||||
All | 146 (38,535) | 0.04 (0.01–0.06) | 0.07 | < 0.01 |
Studies in HWE | 130 (34,679) | 0.02 (0.00–0.05) | 0.24 | 0.05 |
Caucasian | 42 (14,786) | 0.04 (−0.01–0.09) | 0.37 | 0.08 |
Asian | 92 (21,766) | 0.04 (0.01–0.07) | 0.05 | 0.01 |
Chilean | 2 (234) | −0.18 (− 0.47–0.10) | 0.79 | 0.21 |
Brazilian | 2 (223) | 0.22 (−0.13–0.57) | 0.37 | 0.22 |
Indonesian | 4 (531) | −0.18 (− 0.45–0.09) | 0.84 | 0.20 |
Other ethnic | 4 (995) | −0.05 (− 0.19–0.09) | 0.28 | 0.51 |
Female | 38 (10,163) | 0.05 (0.00–0.10) | 0.05 | 0.05 |
Male | 26 (7602) | 0.01 (−0.05–0.06) | 0.30 | 0.83 |
Obesity | 37 (5290) | 0.09 (0.02–0.16) | 0.49 | 0.01 |
T2DM | 17 (3592) | 0.13 (0.05–0.21) | 0.42 | < 0.01 |
Hypertension | 4 (781) | −0.05 (− 0.22–0.13) | 0.28 | 0.61 |
CAD | 7 (1225) | − 0.12 (− 0.25–0.01) | 0.46 | 0.07 |
Healthy | 62 (22,922) | 0.02 (−0.02–0.05) | 0.08 | 0.35 |
Children | 11 (2025) | 0.08 (−0.01–0.18) | 0.68 | 0.08 |
TC | ||||
All | 153 (46,775) | 003 (0.01–0.05) | 0.11 | < 0.01 |
Studies in HWE | 133 (41,641) | 0.03 (0.01–0.06) | 0.17 | 0.01 |
Caucasian | 42 (17,507) | 0.04 (−0.01–0.08) | 0.43 | 0.11 |
Asian | 99 (26,340) | 0.03 (0.01–0.06) | 0.20 | 0.01 |
Chilean | 3 (340) | 0.04 (−0.19–0.27) | 0.83 | 0.73 |
Brazilian | 4 (1310) | 0.09 (−0.06–0.24) | 0.52 | 0.23 |
Other ethnic | 5 (1278) | 0.00 (−0.27–0.27) | < 0.01 | 0.98 |
Female | 36 (11,377) | 0.05 (0.00–0.10) | 0.76 | 0.04 |
Male | 25 (7681) | −0.01 (− 0.06–0.05) | 0.34 | 0.81 |
Obesity | 35 (5269) | 0.08 (0.00–0.15) | 0.70 | 0.04 |
T2DM | 20 (5257) | 0.04 (−0.02–0.11) | 0.75 | 0.22 |
Hypertension | 6 (1182) | 0.04 (−0.10–0.18) | 0.57 | 0.54 |
CAD | 7 (1225) | −0.13 (− 0.26–0.00) | 0.28 | 0.06 |
Healthy | 62 (25,355) | 0.03 (−0.00–0.06) | 0.13 | 0.07 |
Children | 12 (2039) | 0.04 (−0.05–0.14) | 0.39 | 0.36 |
LDL-C | ||||
All | 93 (22,397) | 0.02 (−0.01–0.05) | 0.54 | 0.16 |
Studies in HWE | 81 (19,151) | 0.02 (−0.02–0.05) | 0.49 | 0.38 |
Caucasian | 27 (7116) | −0.01 (− 0.08–0.06) | 0.49 | 0.84 |
Asian | 58 (12,539) | 0.04 (0.00–0.08) | 0.52 | 0.04 |
Brazilian | 3 (1238) | −0.03 (− 0.19–0.12) | 0.20 | 0.67 |
Other ethnic | 4 (1138) | −0.07 (− 0.20–0.06) | 0.85 | 0.31 |
Female | 23 (5740) | 0.04 (−0.03–0.10) | 0.66 | 0.29 |
Male | 17 (2512) | 0.01 (−0.08–0.10) | 0.12 | 0.84 |
Obesity | 29 (4688) | 0.02 (−0.05–0.09) | 0.57 | 0.55 |
T2DM | 8 (1890) | 0.03 (−0.08–0.14) | 0.44 | 0.62 |
CAD | 6 (1040) | −0.05 (− 0.18–0.09) | 0.87 | 0.51 |
Healthy | 34 (9862) | 0.05 (−0.00–0.09) | 0.22 | 0.07 |
Children | 8 (1768) | 0.10 (−0.00–0.20) | 0.42 | 0.06 |
HDL-C | ||||
All | 150 (43,951) | −0.04 (− 0.06--0.02) | 0.55 | 0.01 |
Studies in HWE | 134 (39,781) | −0.03 (− 0.06--0.01) | 0.22 | 0.01 |
Caucasian | 45 (17,720) | −0.04 (− 0.09–0.00) | 0.60 | 0.06 |
Asian | 90 (23,675) | −0.03 (− 0.06--0.01) | 0.05 | 0.02 |
Chilean | 3 (340) | −0.10 (− 0.33–0.13) | 0.37 | 0.38 |
Brazilian | 3 (295) | 0.21 (−0.09–0.50) | 0.42 | 0.17 |
Indonesian | 4 (531) | −0.07 (− 0.34–0.20) | 0.52 | 0.59 |
Other ethnic | 3 (483) | −0.23 (− 042--0.04) | 0.55 | 0.02 |
Female | 38 (11,946) | −0.05 (− 0.10--0.00) | 0.73 | 0.03 |
Male | 27 (8774) | −0.02 (− 0.07–0.03) | 0.13 | 0.50 |
Obesity | 33 (5017) | −0.05 (− 0.10--0.00) | 0.17 | 0.05 |
T2DM | 15 (1923) | −0.15 (− 0.25--0.05) | 0.68 | < 0.01 |
Hypertension | 4 (957) | 0.01 (−0.15–0.16) | 0.10 | 0.91 |
CAD | 7 (1403) | −0.07 (− 0.19–0.06) | 0.09 | 0.31 |
Healthy | 67 (24,960) | −0.02 (− 0.05–0.01) | 0.49 | 0.21 |
Children | 14 (2279) | −0.07 (− 0.15–0.02) | 0.33 | 0.15 |