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Fig. 1 | Lipids in Health and Disease

Fig. 1

From: Omega-3 fatty acid exposure with a low-fat diet in patients with past hypertriglyceridemia-induced acute pancreatitis; an exploratory, randomized, open-label crossover study

Fig. 1

Crossover study design. Details of the assessments at each visit are provided in the methods. aTreatment sequences were: OM3-CA 4 g/day: OM3-EE 4 g/day (n = 4); OM3-EE 4 g/day: OM3-CA 4 g/day (n = 4); OM3-CA 2 g/day: OM3-EE 4 g/day (n = 3); and OM3-EE 4 g/day: OM3-CA 2 g/day (n = 4). bParticipants were given a 4-week supply of the study drug and took their first dose. cPharmacokinetics assessment visit. Study dose was administered in combination with a liquid meal providing 500 kcal (12 g fat, 18 g protein and 80 g carbohydrates). Blood samples were collected before (t = 0) the low-fat load, and 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12 and 24 h afterwards for postprandial assessments of omega-3 fatty acids, TGs, FFAs and apolipoproteins. Participants received breakfast, lunch, dinner and snacks (according to their calculated energy needs for weight maintenance) for consumption in the 2 days before the pharmacokinetics visit. OM3-CA, omega-3 carboxylic fatty acids; OM3-EE, omega-3 ethyl esters

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Lipids in Health and Disease

ISSN: 1476-511X