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Table 4 Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) LPIR associated lipids which are also associated with homeostatic model assessment-insulin resistance (HOMA-IR) in GOLDN compared to HOMA_IR associated lipid species in the HAPI Heart study

From: A lipidome-wide association study of the lipoprotein insulin resistance index

 

GOLDN study

HAPI Heart Study

Metabolites†

β

SE

FDR-correctedP-value‡

β

SE

FDR-correctedP-value‡

CE (18:1)

− 0.137

0.014

8.41E-21

−0.177

0.036

9.70E-06

CE (18:2)

−0.105

0.015

5.14E-12

−0.122

0.038

0.0043

CE (20:3)

−0.057

0.015

0.00029

−0.148

0.034

9.17E-05

CE (20:4)

−0.083

0.015

5.69E-08

−0.114

0.039

0.0086

CE (22:6)

−0.070

0.014

2.65E-06

−0.091

0.039

0.0387

Ceramide (d40:0)

0.093

0.012

4.20E-13

0.113

0.035

0.0033

Ceramide (d42:0)

0.083

0.012

1.59E-10

0.102

0.036

0.0128

DG (32:1)

0.105

0.014

3.41E-13

0.158

0.028

2.90E-07

DG (34:1)

0.115

0.013

8.72E-17

0.184

0.031

1.74E-07

DG (34:2)

0.092

0.014

1.02E-10

0.228

0.037

6.03E-08

DG (36:2)

0.070

0.014

1.76E-06

0.125

0.034

9.00E-04

DG (36:3)

0.054

0.014

0.00031

0.097

0.034

0.0123

DG (38:5)

0.061

0.014

4.79E-05

0.184

0.036

4.80E-06

GlcCer (d42:2)

−0.052

0.015

0.00078

−0.102

0.04

0.0233

LPC (18:1)

−0.051

0.014

0.00070

−0.112

0.037

0.0067

LPC (18:2)

−0.038

0.014

0.01010

−0.081

0.033

0.0291

LPC (20:1)

−0.044

0.013

0.00196

−0.149

0.035

1.00E-04

LPC (22:5)

−0.046

0.015

0.00359

−0.102

0.04

0.023

PC (34:4)

0.039

0.014

0.01240

0.088

0.036

0.0319

PC (37:3)

0.033

0.015

0.04254

−0.093

0.039

0.0345

PC (37:4)

−0.048

0.015

0.00292

−0.095

0.038

0.0281

PC (38:3)

0.061

0.015

9.58E-05

0.176

0.035

5.78E-06

PC (40:4)

0.040

0.015

0.01475

0.171

0.038

5.31E-05

PC (40:6) B

0.031

0.014

0.04002

0.1

0.038

0.0196

PC (42:5)

0.033

0.014

0.04006

0.105

0.039

0.0184

PC (42:6)

0.042

0.015

0.00878

0.135

0.037

0.001

PC (o-32:0)

−0.040

0.015

0.01473

−0.181

0.035

2.45E-06

PC (p-32:0) or PC (o-32:1)

−0.058

0.015

0.00031

−0.221

0.036

4.60E-08

PC (p-34:0) or PC (o-34:1)

−0.095

0.014

9.43E-11

−0.244

0.034

3.85E-10

PC (p-34:1) or PC (o-34:2) B

−0.141

0.013

4.08E-24

−0.302

0.032

6.01E-17

PC (p-34:2) or PC (o-34:3)

−0.090

0.015

4.09E-09

−0.252

0.035

2.28E-10

PC (p-36:1) or PC (o-36:2) A

−0.092

0.013

0.02546

−0.19

0.039

1.31E-05

PC (p-36:2) or PC (o-36:3)

−0.044

0.015

0.00736

−0.177

0.036

1.13E-05

PC (p-36:4) or PC (o-36:5)

−0.054

0.014

0.00044

−0.172

0.038

4.84E-05

PC (p-38:4) or PC (o-38:5) A

−0.058

0.015

0.00032

−0.136

0.038

0.0013

PC (p-38:4) or PC (o-38:5) B

−0.068

0.014

6.66E-06

−0.218

0.036

8.86E-08

PC (p-40:1) or PC (o-40:2)

−0.035

0.015

0.03400

−0.115

0.039

0.0082

PC (p-40:3) or PC (o-40:4)

−0.042

0.015

0.00917

−0.157

0.037

1.00E-04

PC (p-40:4) or PC (o-40:5)

−0.055

0.015

0.00049

−0.198

0.037

1.54E-06

PC (p-40:6) or PC (o-40:7) B

−0.031

0.014

0.04752

−0.186

0.038

1.28E-05

PC (p-42:2) or PC (o-42:3)

−0.069

0.014

4.93E-06

−0.173

0.04

7.84E-05

PC (p-42:3) or PC (o-42:4)

−0.053

0.015

0.00089

−0.111

0.04

0.0123

PC (p-42:4) or PC (o-42:5)

−0.060

0.015

0.00012

−0.201

0.037

1.12E-06

PC (p-42:5) or PC (o-42:6) A

−0.045

0.015

1.07E-06

−0.168

0.04

1.00E-04

PC (p-44:4) or PC (o-44:5)

−0.053

0.015

0.00063

−0.187

0.036

3.09E-06

PC (p-44:5) or PC (o-44:6)

−0.058

0.015

0.00039

−0.121

0.036

0.0028

PE (34:1)

0.080

0.013

1.07E-08

0.116

0.033

0.0017

PE (34:2)

0.073

0.014

2.10E-06

0.129

0.032

3.00E-04

PE (36:1)

0.114

0.014

2.66E-15

0.127

0.027

1.76E-05

PE (36:2)

0.104

0.014

1.40E-13

0.135

0.029

2.09E-05

PE (36:3)

0.069

0.014

4.25E-06

0.06

0.026

0.04

PE (36:4)

0.034

0.013

0.02289

0.092

0.035

0.0196

PE (38:4) B

0.052

0.012

6.71E-05

0.084

0.038

0.0483

PE (38:6)

0.040

0.013

0.00539

0.077

0.034

0.0476

PE (p-40:5) or PE (o-40:6)

−0.037

0.014

0.01636

−0.1

0.042

0.0348

SM (d38:2)

−0.058

0.014

0.00015

−0.171

0.033

2.43E-06

SM (d39:2)

−0.074

0.014

3.75E-07

−0.18

0.034

1.54E-06

SM (d40:2) B

−0.056

0.015

0.00048

−0.157

0.037

1.00E-04

SM (d40:3)

−0.043

0.014

0.00566

−0.197

0.036

1.27E-06

SM (d42:0)

0.040

0.014

0.00740

0.098

0.038

0.023

SM (d42:2) B

−0.038

0.014

0.01437

−0.167

0.037

4.84E-05

SM (d42:3)

−0.054

0.013

0.00010

−0.224

0.036

2.54E-08

TG (40:1)

0.124

0.014

6.21E-17

0.057

0.024

0.0336

TG (42:0)

0.117

0.015

4.86E-14

0.08

0.024

0.0024

TG (42:1)

0.118

0.015

1.01E-14

0.082

0.024

0.0017

TG (44:1)

0.132

0.014

6.00E-19

0.101

0.024

1.00E-04

TG (44:2)

0.133

0.014

6.13E-19

0.116

0.024

1.50E-05

TG (46:0)

0.142

0.014

4.69E-23

0.092

0.024

6.00E-04

TG (46:1)

0.135

0.014

1.33E-20

0.131

0.024

8.49E-07

TG (46:2)

0.132

0.014

5.69E-19

0.136

0.025

7.46E-07

TG (48:0)

0.138

0.014

3.64E-22

0.147

0.028

1.54E-06

TG (49:0)

0.139

0.014

3.00E-22

0.076

0.024

0.005

TG (49:1)

0.133

0.014

2.06E-20

0.115

0.025

2.17E-05

TG (49:3)

0.107

0.014

6.96E-13

0.136

0.03

3.87E-05

TG (50:1)

0.132

0.014

8.68E-21

0.183

0.027

1.77E-09

TG (50:2)

0.121

0.013

2.59E-18

0.189

0.029

1.31E-08

TG (51:1)

0.129

0.014

1.29E-19

0.11

0.024

3.57E-05

TG (51:2)

0.112

0.014

3.28E-15

0.133

0.029

3.79E-05

TG (51:3)

0.091

0.014

5.44E-10

0.125

0.034

9.00E-04

TG (51:4)

0.076

0.015

1.09E-06

0.109

0.034

0.0041

TG (51:5)

0.071

0.015

5.72E-06

0.147

0.036

3.00E-04

TG (52:1)

0.143

0.013

2.38E-25

0.15

0.024

3.79E-08

TG (52:2)

0.062

0.014

4.71E-05

0.163

0.034

1.28E-05

TG (52:3)

0.085

0.014

3.51E-09

0.142

0.035

3.00E-04

TG (52:4)

0.072

0.014

1.78E-06

0.199

0.035

2.51E-07

TG (52:6)

0.065

0.015

2.81E-05

0.217

0.037

1.94E-07

TG (53:1)

0.138

0.014

1.08E-22

0.098

0.023

2.00E-04

TG (53:3)

0.083

0.014

1.74E-08

0.11

0.033

0.0032

TG (53:4)

0.073

0.014

1.79E-06

0.125

0.036

0.002

TG (53:5)

0.055

0.015

0.00048

0.118

0.035

0.0024

TG (54:0)

0.111

0.015

2.43E-13

0.084

0.034

0.0309

TG (54:1)

0.142

0.014

1.47E-23

0.123

0.024

2.45E-06

TG (54:3)

0.060

0.014

7.07E-05

0.095

0.035

0.0177

TG (55:3)

0.083

0.014

2.77E-08

0.081

0.03

0.0168

TG (56:2)

0.125

0.014

1.82E-18

0.141

0.029

8.44E-06

TG (56:4)

0.059

0.015

0.00019

0.1

0.035

0.0119

TG (56:7) B

0.063

0.014

1.78E-05

0.127

0.036

0.0013

TG (56:8) B

0.061

0.014

4.45E-05

0.115

0.036

0.0039

TG (57:2)

0.127

0.014

1.39E-18

0.091

0.025

0.0013

TG (58:1)

0.109

0.014

1.12E-13

0.167

0.031

1.47E-06

TG (58:2)

0.112

0.014

3.38E-14

0.163

0.037

5.74E-05

TG (58:3)

0.097

0.014

8.15E-11

0.149

0.042

0.0015

TG (58:5)

0.073

0.015

3.67E-06

0.128

0.035

0.001

TG (58:6)

0.071

0.014

2.42E-06

0.14

0.034

2.00E-04

TG (60:2)

0.092

0.014

4.06E-10

0.128

0.036

0.0014

  1. *Adjusted for age, sex, BMI, center and family relationship
  2. † Metabolite values were rank-inverse transferred
  3. ‡ P-values were FDR corrected to account for multiple comparisons. Results are shown for significant metabolites (FDR-adjusted P < 0.05). study
  4. Abbreviations: SE Standard Error, CE Cholesteryl ester, DG Diglycerides, LPC Lysophosphatidylcholine, PC Phosphatidylcholine, PE Phosphoethanolamine, SM Sphingomyelin, TG Triglycerides
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Lipids in Health and Disease

ISSN: 1476-511X