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Table 4 Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) LPIR associated lipids which are also associated with homeostatic model assessment-insulin resistance (HOMA-IR) in GOLDN compared to HOMA_IR associated lipid species in the HAPI Heart study

From: A lipidome-wide association study of the lipoprotein insulin resistance index

 GOLDN studyHAPI Heart Study
MetabolitesβSEFDR-correctedP-valueβSEFDR-correctedP-value
CE (18:1)− 0.1370.0148.41E-21−0.1770.0369.70E-06
CE (18:2)−0.1050.0155.14E-12−0.1220.0380.0043
CE (20:3)−0.0570.0150.00029−0.1480.0349.17E-05
CE (20:4)−0.0830.0155.69E-08−0.1140.0390.0086
CE (22:6)−0.0700.0142.65E-06−0.0910.0390.0387
Ceramide (d40:0)0.0930.0124.20E-130.1130.0350.0033
Ceramide (d42:0)0.0830.0121.59E-100.1020.0360.0128
DG (32:1)0.1050.0143.41E-130.1580.0282.90E-07
DG (34:1)0.1150.0138.72E-170.1840.0311.74E-07
DG (34:2)0.0920.0141.02E-100.2280.0376.03E-08
DG (36:2)0.0700.0141.76E-060.1250.0349.00E-04
DG (36:3)0.0540.0140.000310.0970.0340.0123
DG (38:5)0.0610.0144.79E-050.1840.0364.80E-06
GlcCer (d42:2)−0.0520.0150.00078−0.1020.040.0233
LPC (18:1)−0.0510.0140.00070−0.1120.0370.0067
LPC (18:2)−0.0380.0140.01010−0.0810.0330.0291
LPC (20:1)−0.0440.0130.00196−0.1490.0351.00E-04
LPC (22:5)−0.0460.0150.00359−0.1020.040.023
PC (34:4)0.0390.0140.012400.0880.0360.0319
PC (37:3)0.0330.0150.04254−0.0930.0390.0345
PC (37:4)−0.0480.0150.00292−0.0950.0380.0281
PC (38:3)0.0610.0159.58E-050.1760.0355.78E-06
PC (40:4)0.0400.0150.014750.1710.0385.31E-05
PC (40:6) B0.0310.0140.040020.10.0380.0196
PC (42:5)0.0330.0140.040060.1050.0390.0184
PC (42:6)0.0420.0150.008780.1350.0370.001
PC (o-32:0)−0.0400.0150.01473−0.1810.0352.45E-06
PC (p-32:0) or PC (o-32:1)−0.0580.0150.00031−0.2210.0364.60E-08
PC (p-34:0) or PC (o-34:1)−0.0950.0149.43E-11−0.2440.0343.85E-10
PC (p-34:1) or PC (o-34:2) B−0.1410.0134.08E-24−0.3020.0326.01E-17
PC (p-34:2) or PC (o-34:3)−0.0900.0154.09E-09−0.2520.0352.28E-10
PC (p-36:1) or PC (o-36:2) A−0.0920.0130.02546−0.190.0391.31E-05
PC (p-36:2) or PC (o-36:3)−0.0440.0150.00736−0.1770.0361.13E-05
PC (p-36:4) or PC (o-36:5)−0.0540.0140.00044−0.1720.0384.84E-05
PC (p-38:4) or PC (o-38:5) A−0.0580.0150.00032−0.1360.0380.0013
PC (p-38:4) or PC (o-38:5) B−0.0680.0146.66E-06−0.2180.0368.86E-08
PC (p-40:1) or PC (o-40:2)−0.0350.0150.03400−0.1150.0390.0082
PC (p-40:3) or PC (o-40:4)−0.0420.0150.00917−0.1570.0371.00E-04
PC (p-40:4) or PC (o-40:5)−0.0550.0150.00049−0.1980.0371.54E-06
PC (p-40:6) or PC (o-40:7) B−0.0310.0140.04752−0.1860.0381.28E-05
PC (p-42:2) or PC (o-42:3)−0.0690.0144.93E-06−0.1730.047.84E-05
PC (p-42:3) or PC (o-42:4)−0.0530.0150.00089−0.1110.040.0123
PC (p-42:4) or PC (o-42:5)−0.0600.0150.00012−0.2010.0371.12E-06
PC (p-42:5) or PC (o-42:6) A−0.0450.0151.07E-06−0.1680.041.00E-04
PC (p-44:4) or PC (o-44:5)−0.0530.0150.00063−0.1870.0363.09E-06
PC (p-44:5) or PC (o-44:6)−0.0580.0150.00039−0.1210.0360.0028
PE (34:1)0.0800.0131.07E-080.1160.0330.0017
PE (34:2)0.0730.0142.10E-060.1290.0323.00E-04
PE (36:1)0.1140.0142.66E-150.1270.0271.76E-05
PE (36:2)0.1040.0141.40E-130.1350.0292.09E-05
PE (36:3)0.0690.0144.25E-060.060.0260.04
PE (36:4)0.0340.0130.022890.0920.0350.0196
PE (38:4) B0.0520.0126.71E-050.0840.0380.0483
PE (38:6)0.0400.0130.005390.0770.0340.0476
PE (p-40:5) or PE (o-40:6)−0.0370.0140.01636−0.10.0420.0348
SM (d38:2)−0.0580.0140.00015−0.1710.0332.43E-06
SM (d39:2)−0.0740.0143.75E-07−0.180.0341.54E-06
SM (d40:2) B−0.0560.0150.00048−0.1570.0371.00E-04
SM (d40:3)−0.0430.0140.00566−0.1970.0361.27E-06
SM (d42:0)0.0400.0140.007400.0980.0380.023
SM (d42:2) B−0.0380.0140.01437−0.1670.0374.84E-05
SM (d42:3)−0.0540.0130.00010−0.2240.0362.54E-08
TG (40:1)0.1240.0146.21E-170.0570.0240.0336
TG (42:0)0.1170.0154.86E-140.080.0240.0024
TG (42:1)0.1180.0151.01E-140.0820.0240.0017
TG (44:1)0.1320.0146.00E-190.1010.0241.00E-04
TG (44:2)0.1330.0146.13E-190.1160.0241.50E-05
TG (46:0)0.1420.0144.69E-230.0920.0246.00E-04
TG (46:1)0.1350.0141.33E-200.1310.0248.49E-07
TG (46:2)0.1320.0145.69E-190.1360.0257.46E-07
TG (48:0)0.1380.0143.64E-220.1470.0281.54E-06
TG (49:0)0.1390.0143.00E-220.0760.0240.005
TG (49:1)0.1330.0142.06E-200.1150.0252.17E-05
TG (49:3)0.1070.0146.96E-130.1360.033.87E-05
TG (50:1)0.1320.0148.68E-210.1830.0271.77E-09
TG (50:2)0.1210.0132.59E-180.1890.0291.31E-08
TG (51:1)0.1290.0141.29E-190.110.0243.57E-05
TG (51:2)0.1120.0143.28E-150.1330.0293.79E-05
TG (51:3)0.0910.0145.44E-100.1250.0349.00E-04
TG (51:4)0.0760.0151.09E-060.1090.0340.0041
TG (51:5)0.0710.0155.72E-060.1470.0363.00E-04
TG (52:1)0.1430.0132.38E-250.150.0243.79E-08
TG (52:2)0.0620.0144.71E-050.1630.0341.28E-05
TG (52:3)0.0850.0143.51E-090.1420.0353.00E-04
TG (52:4)0.0720.0141.78E-060.1990.0352.51E-07
TG (52:6)0.0650.0152.81E-050.2170.0371.94E-07
TG (53:1)0.1380.0141.08E-220.0980.0232.00E-04
TG (53:3)0.0830.0141.74E-080.110.0330.0032
TG (53:4)0.0730.0141.79E-060.1250.0360.002
TG (53:5)0.0550.0150.000480.1180.0350.0024
TG (54:0)0.1110.0152.43E-130.0840.0340.0309
TG (54:1)0.1420.0141.47E-230.1230.0242.45E-06
TG (54:3)0.0600.0147.07E-050.0950.0350.0177
TG (55:3)0.0830.0142.77E-080.0810.030.0168
TG (56:2)0.1250.0141.82E-180.1410.0298.44E-06
TG (56:4)0.0590.0150.000190.10.0350.0119
TG (56:7) B0.0630.0141.78E-050.1270.0360.0013
TG (56:8) B0.0610.0144.45E-050.1150.0360.0039
TG (57:2)0.1270.0141.39E-180.0910.0250.0013
TG (58:1)0.1090.0141.12E-130.1670.0311.47E-06
TG (58:2)0.1120.0143.38E-140.1630.0375.74E-05
TG (58:3)0.0970.0148.15E-110.1490.0420.0015
TG (58:5)0.0730.0153.67E-060.1280.0350.001
TG (58:6)0.0710.0142.42E-060.140.0342.00E-04
TG (60:2)0.0920.0144.06E-100.1280.0360.0014
  1. *Adjusted for age, sex, BMI, center and family relationship
  2. † Metabolite values were rank-inverse transferred
  3. P-values were FDR corrected to account for multiple comparisons. Results are shown for significant metabolites (FDR-adjusted P < 0.05). study
  4. Abbreviations: SE Standard Error, CE Cholesteryl ester, DG Diglycerides, LPC Lysophosphatidylcholine, PC Phosphatidylcholine, PE Phosphoethanolamine, SM Sphingomyelin, TG Triglycerides