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Table 5 The effect size of FPG on NAFLD in prespecified and exploratory subgroups in each subgroup

From: Association between fasting plasma glucose and nonalcoholic fatty liver disease in a nonobese Chinese population with normal blood lipid levels: a prospective cohort study

Characteristic

No. of participants

HR (95%CI)

P-value

P for interaction

Age (years)

   

0.0757

 ≤ 30

2288

1.41 (1.24, 1.61)

< 0.0001

 

 > 30, ≤60

6179

1.20 (1.13, 1.28)

< 0.0001

 

 > 60

1300

1.16 (1.03, 1.32)

0.0184

 

Sex

   

0.0633

 Men

5022

1.17 (1.10, 1.25)

< 0.0001

 

 Women

4745

1.30 (1.19, 1.42)

< 0.0001

 

BMI, kg/m2

   

0.5383

 ≤ 18.5

1115

2.51 (0.34, 18.43)

0.3668

 

 18.6–25

8652

1.23 (1.17, 1.29)

< 0.0001

 

Height, m

   

0.0271

 < 1.635

4807

1.33 (1.22, 1.46)

< 0.0001

 

 ≥ 1.635

4960

1.18 (1.10, 1.25)

< 0.0001

 

Cr, mmol/L

   

0.1052

 < 104

9007

1.20 (1.14, 1.27)

< 0.0001

 

 ≥ 104

760

1.43 (1.17, 1.75)

0.0005

 

UA, μmol/L

   

0.5569

 < 416

9352

1.21 (1.15, 1.27)

< 0.0001

 

 ≥416

415

1.10 (0.80, 1.51)

0.5488

 

TC, mmol/L

   

0.0003

 < 4.39

4844

1.40 (1.29, 1.52)

< 0.0001

 

 4.39–5.2

4923

1.14 (1.07, 1.23)

0.0001

 

TG, mmol/L

   

0.0203

 < 0.93

4824

1.41 (1.26, 1.59)

< 0.0001

 

 0.93–1.7

4943

1.20 (1.13, 1.27)

< 0.0001

 

LDL-C, mmol/L

   

0.0099

 < 2.14

4883

1.35 (1.23, 1.47)

< 0.0001

 

 2.14–3.12

4884

1.16 (1.09, 1.24)

< 0.0001

 

HDL-C, mmol/L

   

0.0024

 ≥ 1.04, < 1.48

4783

1.34 (1.24, 1.45)

< 0.0001

 

 ≥ 1.48

4984

1.14 (1.05, 1.23)

< 0.0001

 

ALP, U/L

   

0.0109

 < 67

3531

1.50 (1.28, 1.75)

< 0.0001

 

 ≥ 67

6236

1.20 (1.13, 1.27)

< 0.0001

 

GGT, U/L

   

< 0.0001

 < 40

9032

1.35 (1.26, 1.45)

< 0.0001

 

 ≥ 40

735

1.07 (0.97, 1.18)

0.1677

 

ALT, U/L

   

< 0.0001

 < 40

9445

1.30 (1.22, 1.39)

< 0.0001

 

 ≥ 40

322

1.01 (0.87, 1.16)

0.9230

 

AST, U/L

   

< 0.0001

 < 40

9579

1.31 (1.23, 1.39)

< 0.0001

 

 ≥ 40

188

0.97 (0.81, 1.16)

0.7304

 

ALB, g/L

   

0.0008

 < 44.29

4269

1.16 (1.08, 1.24)

< 0.0001

 

 ≥ 44.29

5498

1.40 (1.28, 1.53)

< 0.0001

 

GLB, g/L

   

0.0031

 < 29.44

4637

1.36 (1.25, 1.48)

< 0.0001

 

 ≥ 29.44

5130

1.15 (1.08, 1.23)

< 0.0001

 

DBIL, g/L

   

0.2803

 < 2.1

2532

1.27 (1.15, 1.39)

< 0.0001

 

 ≥ 2.1

7235

1.19 (1.12, 1.27)

< 0.0001

 

SBP, mmHg

   

0.3633

 < 140

8788

1.19 (1.12, 1.27)

< 0.0001

 

 ≥ 140

979

1.26 (1.14, 1.40)

< 0.0001

 

DBP, mmHg

   

0.2046

 < 90

9253

1.19 (1.12, 1.26)

< 0.0001

 

 ≥ 90

514

1.31 (1.15, 1.48)

< 0.0001

 
  1. Note 1: The above model adjusted for sex, Age, Cr, UA, TC, TG, HDL-C, LDL-C, Height, BMI, ALP, GGT, ALT, AST, ALB, GLB, DBIL, SBP, and DBP
  2. Note 2: In each case, the model is not adjusted for the stratification variable
  3. Abbreviations: CI Confidence, HR Hazard ratios
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Lipids in Health and Disease

ISSN: 1476-511X