Fig. 3

Niacin alters the HDL proteome. The HDL proteome was analyzed at baseline and after 16 weeks on niacin (2 g/day, extended release). (a) Changes to the HDL proteome are represented in a volcano plot. Each point indicates one of the 63 detected proteins. Proteins above the horizontal line were considered statistically significant changes. Green colored points indicate proteins increased while taking niacin and red points indicate reduced protein abundance while taking niacin. (b) Functional annotation of proteins affected by niacin was performed using Panther (version 14.1) gene list analysis [17, 18]