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Table 3 Adjusted means in obesity status and serum lipid profiles of participants with major-, heterozygote-, and minor-alleles of the haplotype1 according to serum LDL cholesterol concentrations

From: A minor allele of the haplotype located in the 19q13 loci is associated with a decreased risk of hyper-LDL-cholesterolemia, and a balanced diet and high protein intake can reduce the risk

  Low-LDL2 High-LDL3
  Major4
(n = 10,950)
Heterozygote
(n = 10,728)
Minor
(n = 2731)
Major
(n = 1782)
Heterozygote
(n = 1680)
Minor
(n = 301)
BMI (kg/m2) 23.8 ± 2.8b 23.9 ± 2.9b 23.9 ± 2.8b 24.3 ± 2.9a 24.4 ± 2.8a 24.2 ± 2.6b+++
WC (cm) 80.6 ± 8.7b 80.8 ± 8.8b 80.7 ± 8.6b 81.9 ± 8.3a 81.8 ± 8.2a 81.3 ± 7.4b+++
Total cholesterol (mg/dl) 191 ± 29b 190 ± 29b 186 ± 30c 238 ± 40a 239 ± 41a 235 ± 48a***+++
LDL (mg/dl) 114 ± 25c 112 ± 26d 106 ± 26e 159 ± 39a 158 ± 41a 153 ± 47b***+++
HDL (mg/dl) 52.6 ± 13 52.8 ± 13 53.3 ± 13 53.2 ± 12 53.1 ± 11 53.2 ± 12
TG (mg/dl) 123 ± 88a 125 ± 87ab 132 ± 91c 131 ± 77bc 136 ± 71bc 143 ± 83c**+++
Ratio of LDL/ HDL 2.34 ± 0.70b 2.31 ± 0.72b 2.22 ± 0.70c 2.65 ± 1.04a 2.62 ± 1.02a 2.56 ± 1.65a***+++
  1. 1Haplotypes of APOE, PVRL2, TOMM40, EXOC3L2, and CD3EAP in the 19q13 loci; 2 Low serum LDL cholesterol < 160 mg/dl and 3 High serum LDL cholesterol ≥160 mg/dl; 4Major, heterozygotes, and minor alleles of each SNP were scored 0, 1, and 2, respectively, and the scores of the SNPs in the haplotype were added. They were divided into 3 categories (Major, Heterozygote, and Minor haplotype groups) by 0, 1–2, and 3–4, respectively. Adjusted for age, gender, residence area, body mass index (BMI), and energy intake. Values represent adjusted means±standard deviations
  2. Significantly different from major allele group at *P < 0.05; **P < 0.01; ***P < 0.001. Significantly different by LDL status +P < 0.05; ++P < 0.01; +++P < 0.001
  3. a,b,c Means without a common letter differ in the same row by Bonferroni test at P < 0.05