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Table 3 Adjusted means in obesity status and serum lipid profiles of participants with major-, heterozygote-, and minor-alleles of the haplotype1 according to serum LDL cholesterol concentrations

From: A minor allele of the haplotype located in the 19q13 loci is associated with a decreased risk of hyper-LDL-cholesterolemia, and a balanced diet and high protein intake can reduce the risk

 

Low-LDL2

High-LDL3

 

Major4

(n = 10,950)

Heterozygote

(n = 10,728)

Minor

(n = 2731)

Major

(n = 1782)

Heterozygote

(n = 1680)

Minor

(n = 301)

BMI (kg/m2)

23.8 ± 2.8b

23.9 ± 2.9b

23.9 ± 2.8b

24.3 ± 2.9a

24.4 ± 2.8a

24.2 ± 2.6b+++

WC (cm)

80.6 ± 8.7b

80.8 ± 8.8b

80.7 ± 8.6b

81.9 ± 8.3a

81.8 ± 8.2a

81.3 ± 7.4b+++

Total cholesterol (mg/dl)

191 ± 29b

190 ± 29b

186 ± 30c

238 ± 40a

239 ± 41a

235 ± 48a***+++

LDL (mg/dl)

114 ± 25c

112 ± 26d

106 ± 26e

159 ± 39a

158 ± 41a

153 ± 47b***+++

HDL (mg/dl)

52.6 ± 13

52.8 ± 13

53.3 ± 13

53.2 ± 12

53.1 ± 11

53.2 ± 12

TG (mg/dl)

123 ± 88a

125 ± 87ab

132 ± 91c

131 ± 77bc

136 ± 71bc

143 ± 83c**+++

Ratio of LDL/ HDL

2.34 ± 0.70b

2.31 ± 0.72b

2.22 ± 0.70c

2.65 ± 1.04a

2.62 ± 1.02a

2.56 ± 1.65a***+++

  1. 1Haplotypes of APOE, PVRL2, TOMM40, EXOC3L2, and CD3EAP in the 19q13 loci; 2 Low serum LDL cholesterol < 160 mg/dl and 3 High serum LDL cholesterol ≥160 mg/dl; 4Major, heterozygotes, and minor alleles of each SNP were scored 0, 1, and 2, respectively, and the scores of the SNPs in the haplotype were added. They were divided into 3 categories (Major, Heterozygote, and Minor haplotype groups) by 0, 1–2, and 3–4, respectively. Adjusted for age, gender, residence area, body mass index (BMI), and energy intake. Values represent adjusted means±standard deviations
  2. Significantly different from major allele group at *P < 0.05; **P < 0.01; ***P < 0.001. Significantly different by LDL status +P < 0.05; ++P < 0.01; +++P < 0.001
  3. a,b,c Means without a common letter differ in the same row by Bonferroni test at P < 0.05