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Table 2 The association between polymorphisms of CYP1A1 and CYP1A2 and stroke risk

From: The influence of CYP1A1 and CYP1A2 polymorphisms on stroke risk in the Chinese population

SNP-ID

Model

Genotype

Frequency

Without adjustment

With adjustment

Case

Control

OR (95% CI)

Pa-value

OR (95% CI)

Pb-value

rs1048943

codominant

C/C

28

27

1

 

1

 
  

C/T

167

185

0.86 (0.66–1.12)

0.262

0.86 (0.66–1.13)

0.284

  

T/T

282

268

0.99 (0.57–1.72)

0.959

0.98 (0.56–1.71)

0.950

 

dominant

C/C

28

27

1

 

1

 
  

C/T-T/T

449

453

0.87 (0.68–1.13)

0.304

0.88 (0.68–1.14)

0.324

 

recessive

C/C-C/T

195

212

1

 

1

 
  

T/T

282

268

1.05 (0.61–1.80)

0.871

1.04 (0.60–1.80)

0.889

 

log-additive

–

–

–

0.92 (0.75–1.14)

0.436

0.92 (0.75–1.138)

0.451

rs4646422

codominant

T/T

12

11

1

 

1

 
  

T/C

128

135

0.94 (0.70–1.25)

0.654

0.94 (0.70–1.25)

0.651

  

C/C

336

332

1.08 (0.47–2.48)

0.860

1.07 (0.46–2.46)

0.876

 

dominant

T/T

12

11

1

 

1

 
  

T/C-C/C

464

467

0.95 (0.72–1.25)

0.703

0.95 (0.72–1.25)

0.696

 

recessive

T/T-T/C

140

146

1

 

1

 
  

C/C

336

332

1.10 (0.48–2.51)

0.825

1.09 (0.48–2.49)

0.840

 

log-additive

–

–

–

0.97 (0.76–1.24)

0.785

0.96 (0.75–1.23)

0.775

rs762551

codominant

C/C

58

90

1

 

1

 
  

A/C

245

228

0.99 (0.75–1.32)

0.965

0.99 (0.75–1.31)

0.947

  

A/A

173

160

0.60 (0.40–0.88)

0.010

0.60 (0.40–0.88)

0.010

 

dominant

C/C

58

90

1

 

1

 
  

A/C-A/A

418

388

0.88 (0.68–1.15)

0.352

0.88 (0.67–1.15)

0.341

 

recessive

C/C-A/C

303

318

1

 

1

 
  

A/A

173

160

0.60 (0.42–0.86)

0.005

0.60 (0.42–0.86)

0.005

 

log-additive

–

–

–

0.81 (0.68–0.98)

0.032

0.81 (0.68–0.98)

0.031

rs2470890

codominant

T/T

8

6

1

 

1

 
  

T/C

102

101

1.03 (0.75–1.40)

0.856

1.02 (0.75–1.40)

0.883

  

C/C

366

373

1.36 (0.47–3.96)

0.574

1.35 (0.46–3.95)

0.579

 

dominant

T/T

8

6

1

 

1

 
  

T/C-C/C

468

474

1.05 (0.77–1.42)

0.763

1.04 (0.77–1.41)

0.791

 

recessive

T/T-T/C

110

107

1

 

1

 
  

C/C

366

373

1.35 (0.47–3.92)

0.581

1.35 (0.46–3.92)

0.585

 

log-additive

–

–

–

1.06 (0.81–1.40)

0.676

1.06 (0.80–1.39)

0.701

  1. SNP Single nucleotide polymorphism, OR Odds ratio, 95% CI 95% confidence interval
  2. Pa-values were calculated by logistic regression analysis withoutment
  3. Pb-values were calculated by logistic regression analysis adjusted for gender and age
  4. *Bold-face values indicate statistical significance (P < 0.05)
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Lipids in Health and Disease

ISSN: 1476-511X