Table 4 The association between CYP1A1 and CYP1A2 polymorphisms and stroke risk in patients with hypertension and coronary heart disease

 CYP1A1

rs4646422

Allele

T

111

41

1

C

567

233

1.11 (0.75–1.64)

0.591

codominant

T/T

5

7

1

T/C

101

27

1.69 (1.04–2.74)

0.035^*

C/C

233

103

0.32 (0.10–1.03)

0.055

dominant

T/T

5

7

1

T/C-C/C

334

130

1.40 (0.89–2.21)

0.142

recessive

T/T-T/C

106

34

1

C/C

233

103

0.28 (0.09–0.89)

0.032^*

log-additive

–

–

–

1.13 (0.76–1.67)

0.546

 CYP1A2

rs762551

Allele

C

267

94

1

A

411

180

1.24 (0.93–1.67)

0.144

codominant

C/C

41

17

1

A/C

185

60

1.65 (1.08–2.54)

0.022^*

A/A

113

60

1.28 (0.67–2.46)

0.451

dominant

C/C

41

17

1

A/C-A/A

298

120

1.57 (1.04–2.36)

0.030^*

recessive

C/C-A/C

226

77

1

A/A

113

60

0.97 (0.53–1.78)

0.918

log-additive

–

–

–

1.28 (0.94–1.74)

0.122

rs2470890

Allele

T

94

24

1

C

584

250

1.68 (1.05–2.69)

0.030^*

codominant

T/T

6

2

1

T/C

82

20

1.91 (1.11–3.27)

0.019^*

C/C

251

115

1.22 (0.24–6.22)

0.809

dominant

T/T

6

2

1

T/C-C/C

333

135

1.85 (1.10–3.10)

0.021^*

recessive

T/T-T/C

88

22

1

C/C

251

115

1.08 (0.21–5.47)

0.928

log-additive

–

–

–

1.67 (1.04–2.70)

0.035^*

 CYP1A1

rs4646422

Allele

T

43

109

1

C

163

637

1.54 (1.04–2.28)

0.030^*

codominant

T/T

3

9

1

T/C

37

91

1.79 (1.11–2.90)

0.017^*

C/C

63

273

1.32 (0.34–5.12)

0.690

dominant

T/T

3

9

1

T/C-C/C

100

364

1.75 (1.10–2.78)

0.019^*

recessive

T/T-T/C

40

100

1

C/C

63

273

1.10 (0.29–4.24)

0.886

log-additive

–

–

–

1.54 (1.03–2.30)

0.036^*

 CYP1A2

rs2470890

Allele

T

18

100

1

C

188

646

0.62 (0.37–1.05)

0.072

codominant

T/T

1

7

1

T/C

16

86

0.57 (0.31–1.03)

0.060

C/C

86

280

0.43 (0.05–3.67)

0.444

dominant

T/T

1

7

1

T/C-C/C

102

366

0.56 (0.31–0.99)

0.047^*

recessive

T/T-T/C

17

93

1

C/C

86

280

0.49 (0.06–4.10)

0.508

log-additive

–

–

–

0.58 (0.34–1.00)

0.049