Table 2 Genotypes and allele distribution of APOE gene in cerebral infarction patients and control participants in total and according to gender

Genotypes

ɛ2/ɛ2

ɛ2/ɛ3

ɛ2/ɛ4

ɛ3/ɛ3

ɛ3/ɛ4

ɛ4/ɛ4

All subjects

11 (0.56%)

194 (9.87%)

31 (1.58%)

1447 (73.60%)

262 (13.33%)

21 (1.07%)

 Patients(n = 938)

2 (0.21%)

63 (6.72%)

18 (1.92%)

684 (72.92%)

156 (16.63%)

15 (1.60%)

 Controls(n = 1028)

9 (0.88%)

131 (12.74%)

13 (1.26%)

763 (74.22%)

106 (10.31%)

6 (0.58%)

 P values (Patients vs controls)

0.049

< 0.001

0.279

0.513

< 0.001

0.029

 Patients(n = 581)

2 (0.34%)

41 (7.06%)

16 (2.75%)

409 (70.40%)

104 (17.90%)

9 (1.55%)

 Controls(n = 622)

4 (0.64%)

86 (13.83%)

8 (1.29%)

458 (73.63%)

63 (10.13%)

3 (0.48%)

 P values (Patients vs controls)

–

< 0.001

0.069

0.211

< 0.001

–

 Patients(n = 357)

0 (0)

22 (6.16%)

2 (0.56%)

275 (77.03%)

52 (14.57%)

6 (1.68%)

 Controls(n = 406)

5 (1.23%)

45 (11.08%)

5 (1.23%)

305 (75.12%)

43 (10.59%)

3 (0.74%)

 P values (Patients vs controls)

–

0.017

0.458

0.538

0.097

–

Alleles

ɛ2

ɛ3

ɛ4

All subjects(n = 3932)

247 (6.28%)

3350 (85.20%)

335 (8.52%)

 Patients(n = 1876)

85 (4.53%)

1587 (84.59%)

204 (10.87%)

 Controls(n = 2056)

162 (7.88%)

1763 (85.75%)

131 (6.37%)

 P values (Patients vs controls)

< 0.001

0.309

< 0.001

 Patients(n = 1162)

61 (5.25%)

963 (82.87%)

138 (11.88%)

 Controls(n = 1244)

102 (8.20%)

1065 (85.61%)

77 (6.19%)

 P values (Patients vs controls)

0.004

0.065

< 0.001

 Patients(n = 714)

24 (3.36%)

624 (87.39%)

66 (9.24%)

 Controls(n = 812)

60 (7.39%)

698 (85.96%)

54 (6.65%)

 P values (Patients vs controls)

0.001

0.411

0.060