Association between triglyceride-glucose index and risk of incident diabetes: a secondary analysis based on a Chinese cohort study

Table 4 Effect of magnitude of TyG index on diabetes risk stratified by subgroups

Characteristics	No. of participants	HR (95%CI)	P-value	P for interaction
Age (year)				< 0.0001
< 40	106,447	4.53 (3.76–5.45)	< 0.0001
> =40, < 60	71,176	3.54 (3.19–3.93)	< 0.0001
> =60	23,675	2.67 (2.37–3.00)	< 0.0001
Sex				0.0150
Male	109,236	3.16 (2.90–3.45)	< 0.0001
Female	92,062	3.84 (3.37–4.37)	< 0.0001
BMI (kg/m²)				0.0075
< 18.5	11,593	3.64 (1.53–8.64)	0.0034
> =18.5, < 24	112,241	4.13 (3.62–4.71)	< 0.0001
> =24, < 28	60,886	3.22 (2.90–3.58)	< 0.0001
> =28, < 32	14,388	3.11 (2.64, 3.68)	< 0.0001
> =32	2190	3.36 (2.33, 4.85)	< 0.0001
SBP (mmHg)				< 0.0001
< 140	181,383	3.48 (3.19–3.79)	< 0.0001
> =140	19,915	2.89 (2.53–3.29)	< 0.0001
DBP (mmHg)				0.9984
< 90	185,636	3.29 (3.04–3.56)	< 0.0001
> =90	15,661	3.43 (2.90–4.05)	< 0.0001
Smoker				0.6979
Now	11,071	3.03 (2.36–3.90)	< 0.0001
Once	2419	4.27 (2.30–7.91)	< 0.0001
Never	43,497	3.40 (2.84–4.08)	< 0.0001
Not recorded	144,311	3.39 (3.13–3.69)	< 0.0001
Drinker				0.2174
Now	1243	5.31 (2.34–12.05)	< 0.0001
Once	8496	3.65 (2.52–5.28)	< 0.0001
Never	47,248	3.33 (2.84–3.90)	< 0.0001
Not recorded	144,311	3.39 (3.13–3.69)	< 0.0001
Family history of diabetes				0.1175
No	197,196	3.39 (3.15–3.65)	< 0.0001
Yes	4102	3.07 (2.10–4.50)	< 0.0001

Note 1: the model was adjusted for sex, age, BMI, LDL-C, TC, Scr, ALT, AST, SBP, DBP, drinking, smoking and family history of diabetes
Note 2: the model was adjusted for all above variables except the corresponding stratification variable

ISSN: 1476-511X