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Table 3 Performance of individual and combined factors in predicting FHTG compared to CHTG using logistic regression analyses. *Model adjusted for age

From: Familial hypertriglyceridemia: an entity with distinguishable features from other causes of hypertriglyceridemia

Variable

AUC

(95% CI)

Cut-off value

BIC

Sensitivity (95%CI)

Specificity (95%CI)

PPV

(95%CI)

NPV

(95%CI)

Age (years)

0.633 (0.539–0.727)

< 45.0

217.80

72.6(61.8–81.8)

67.0 (56.0–76.9)

68.8 (58.0–78.1)f

66.3 (55.4–76.2)

Apo B (mg/dL)

0.853(0.787–0.918)

< 102.0

145.29

92.8 (85.1–97.3)

73.3 (61.8–82.9)

81.8 (68.5–87.4)

57.6 (46.4–76.5)

Apo A-II (mg/dL)

0.878(0.824–0.932)

> 0.472

143.22

85.7 (76.4–92.4)

78.8 (68.6–86.9)

77.0 (65.2–83.8)

60.9 (50.3–74.9)

ANGPTL3 (ng/mL)

0.530(0.433–0.628)

> 214.7

199.56

48.8 (37.7–60.0)

91.5 (82.5–96.8)

87.2 (74.8–91.5)

60.2 (49.0–81.0)

FGF-21(pg/mL)

0.804(0.737–0.872)

> 27.0

204.70

96.4 (89.9–99.2)

57.6 (46.4–68.3)

60.0 (28.7–81.9)

47.9 (15.7–88.5)

Sex + Apo B < 102 mg/ dL

0.858 (0.799–0.917)

> 0.66

149.91

90.5 (82.1 98.9)

73.2 (61.4–85.0)

80.0 (69.9–90.1)

86.7 (75.8 97.6)

Apo B < 102 mg/dL + apo A-II > 0.472 mg/dL

0.917 (0.874–0.960)

> 0.94

114.62

76.2 (65.6–84.8)

92.9 (84.3–97.7)

92.7 (83.9–95.7)

76.7 (66.3–91.3)

Apo B < 102 mg/dL + apo A-II > 0.472 mg/dL + Sex

0.934 (0.894–0.975)

> 0.49

113.6

95.2 (88.2–98.7)

78.9 (67.6–87.7)

84.2(74.8–95.2)

93.3 (84.0–96.4)

Apo B < 102 mg/dL + apo A-II > 0.472 mg/dL + Sex*

0.944 (0.908–0.981)

> 0.64

114.09

89.3 (80.6–95.0)

85.9 (75.6–93.0)

88.2 (79.2–94.4)

87.1 (77.2–93.7)

Apo B < 102 mg/dL + apo AII > 0.472 mg/dL + Sex + FGF-21 > 27 pg/mL, ANGPTL3 > 214 ng/mL*

0.969 (0.920–0.999)

> 0.45

107.88

98.9 (94.5–99.9)

92.5(78–92)

89.3 (80.7–99.7)

98.7 (92.3–99.2)

  1. PPV Positive predictive value; NPV Negative predictive value; AUC Area under curve; BIC Bayesian information Crite