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Fig. 1 | Lipids in Health and Disease

Fig. 1

From: Paradigm shift: the primary function of the “Adiponectin Receptors” is to regulate cell membrane composition

Fig. 1

The role of PAQR-2 in membrane homeostasis. Conditions that promote membrane rigidification, such as SFA-rich diets or low temperature, stimulate the formation, hence activation, of the PAQR-2/IGLR-2 complex. While PAQR-2 is definitely an ADIPOR ortholog, no functional homolog of IGLR-2 has yet been identified in mammals. Genetic studies reveal that two downstream branches mediate the effects of the PAQR-2/IGLR-2 complex: (1) Branch 1 stimulates the transcription of fatty acid desaturase genes and can be replaced by gain-of-function mutations in NHR-49 (homologous to the mammalian PPARs), MDT-15 or SBP-1; and (2) Branch 2 stimulates the production/incorporation of PUFAs into phospholipids and can be replaced by loss-of-function mutations in FLD-1 (homologous to the mammalian TLCD1/2 proteins) or ACS-13. The ultimate output of PAQR-2 signaling is to increase the UFA content in phospholipids, which promotes fluidity

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Lipids in Health and Disease

ISSN: 1476-511X