Table 2 Performance metrics for all three formulas compared to LDL-C estimated using VLDL-C measured by ultracentrifugation in the overall population and stratified by FCHL dyslipidemia phenotype

ρ (95%CI)

0.895 (0.872–0.915)

0.899 (0.876–0.917)

0.917 (0.899–0.932)

0.962 (0.947–0.973)

0.957 (0.941–0.969)

0.961 (0.9460.972)

0.855 (0.814–0.889)

0.871 (0.834–0.901)

0.875 (0.838–0.904)

ρ with ApoB (95%CI)

0.644 (0.577–0.702)

0.788 (0.744–0.825)

0.704 (0.646–0.754)

0.856 (0.825–0.882)

0.868 (0.8400.892)

0.862 (0.832–0.887)

0.628 (0.558–0.688)

0.729 (0.675–0.775)

0.662 (0.598–0.718)

R2

0.802

0.807

0.840

0.645

0.606

0.614

0.731

0.769

0.782

RMSE

44.96

30.22

19.99

10.74

10.98

10.19

44.44

29.41

18.41

Bias (95%CI)

12.33 (7.71,16.95)

1.12 (−2.10,4.35)

4.59 (2.51,6.67)

2.85 (2.16,5.56)

4.14 (2.41,5.86)

2.29 (0.59,4.00)

18.05 (10.47,25.63)

−0.91 (−6.19,4.37)

6.14 (2.86,9.42)