Characteristic | No. of participants | HR (95%CI) | P-value | P-interaction |
---|---|---|---|---|
Clinical baseline subgroup | ||||
 Age (years) |  |  |  | 0.1504 |
   < 30 | 2016 | 0.80 (0.40, 1.61) | 0.5334 |  |
   ≥ 30, < 45 | 4220 | 0.70 (0.47, 1.02) | 0.0623 |  |
   ≥ 45, < 60 | 2740 | 0.37 (0.22, 0.63) | 0.0002 |  |
   ≥ 60 | 1754 | 0.82 (0.42, 1.61) | 0.5648 |  |
 Sex |  |  |  | 0.9157 |
  Men | 5891 | 0.61 (0.43, 0.88) | 0.0073 |  |
  Women | 4839 | 0.63 (0.42, 0.94) | 0.0252 |  |
 BMI, kg/m2 |  |  |  | 0.0076 |
   ≤ 18.5 | 821 | 86.13 (5.86, 968.98) | 0.0012 |  |
  18.6–25 | 9909 | 0.60 (0.46, 0.79) | 0.0003 |  |
 SBP, mmHg |  |  |  | 0.0292 |
   < 140 | 9076 | 0.54 (0.40, 0.74) | 0.0001 |  |
   ≥ 140 | 1657 | 0.94 (0.70, 1.28) | 0.7140 |  |
 DBP, mmHg |  |  |  | 0.0003 |
   < 90 | 9857 | 0.48 (0.35, 0.65) | < 0.0001 |  |
   ≥ 90 | 876 | 1.15 (0.89, 1.49) | 0.2748 |  |
Liver function subgroup | ||||
 GGT, U/L |  |  |  | 0.8335 |
   < 40 | 8977 | 0.63 (0.47, 0.84) | 0.0016 |  |
  ≥ 40 | 1770 | 0.67 (0.41, 1.08) | 0.0996 |  |
 ALT, U/L |  |  |  | 0.8653 |
   < 40 | 10,109 | 0.61 (0.46, 0.81) | 0.0008 |  |
   ≥ 40 | 640 | 0.57 (0.24, 1.34) | 0.1948 |  |
 AST, U/L |  |  |  | 0.6524 |
   < 40 | 10,419 | 0.69 (0.52, 0.90) | 0.0063 |  |
   ≥ 40 | 330 | 0.48 (0.10, 2.32) | 0.8708 |  |
Kidney function subgroup | ||||
 Cr, mmol/L |  |  |  | 0.0247 |
   < 108 | 9809 | 0.23 (0.17, 0.30) | < 0.0001 |  |
   ≥ 104 | 937 | 1.37 (0.68, 2.76) | 0.3732 |  |
Blood glucose metabolism subgroup | ||||
 FPG, mmol/L |  |  |  | 0.4721 |
   < 6.1 | 9931 | 0.58 (0.43, 0.77) | 0.0002 |  |
   ≥ 6.1 | 799 | 0.76 (0.38, 1.55) | 0.4578 |  |
Lipid metabolism subgroup | ||||
 TC, mmol/L |  |  |  | 0.0059 |
   < 5.2 | 8372 | 0.48 (0.35, 0.67) | < 0.0001 |  |
   ≥ 5.2 | 2358 | 0.93 (0.70, 1.23) | 0.5994 |  |
 TG, mmol/L |  |  |  | 0.0155 |
   < 1.7 | 8348 | 0.48 (0.33, 0.68) | < 0.0001 |  |
   ≥ 1.7 | 2382 | 0.88 (0.62, 1.25) | 0.4658 |  |
 HDL-C, mmol/L |  |  |  | 0.0340 |
   < 0.9 | 392 | 2.01 (0.63, 6.38) | 0.2368 |  |
   ≥ 0.9 | 10,338 | 0.55 (0.45, 0.77) | < 0.0001 |  |