High-density Lipoprotein Cholesterol Is Negatively Correlated with Bone Mineral Density and Has Potential Predictive Value for Bone Loss

Tang, Yuchen; Wang, Shenghong; Yi, Qiong; Xia, Yayi; Geng, Bin

doi:10.1186/s12944-021-01497-7

Lipids in Health and Disease

Table 5 Association between HDL-C and BMD in males

From: High-density Lipoprotein Cholesterol Is Negatively Correlated with Bone Mineral Density and Has Potential Predictive Value for Bone Loss

		Model 1 β (95% CI) P value	Model 2 β (95% CI) P value	Model 3 β (95% CI) P value
Total femur BMD	20≤Aged<30	-0.0006 (-0.0013, 0.0001) 0.118476	-0.0009 (-0.0016, -0.0001) 0.017990	0.0001 (-0.0007, 0.0009) 0.776354
	30≤Aged<40	-0.0014 (-0.0021, -0.0008) 0.000015	-0.0015 (-0.0022, -0.0009) 0.000003	-0.0008 (-0.0015, -0.0001) 0.019154
	40≤Aged<50	-0.0007 (-0.0012, -0.0001) 0.028729	-0.0009 (-0.0015, -0.0003) 0.003117	0.0001 (-0.0006, 0.0007) 0.820437
	50≤Aged<60	-0.0013 (-0.0021, -0.0006) 0.000698	-0.0017 (-0.0024, -0.0009) 0.000026	-0.0005 (-0.0014, 0.0003) 0.203276
	60≤Aged	-0.0011 (-0.0018, -0.0004) 0.002495	-0.0012 (-0.0019, -0.0005) 0.000605	-0.0004 (-0.0011, 0.0003) 0.220103
Femur neck BMD	20≤Aged<30	-0.0005 (-0.0012, 0.0002) 0.165831	-0.0008 (-0.0015, -0.0001) 0.032699	0.0002 (-0.0006, 0.0010) 0.639104
	30≤Aged<40	-0.0010 (-0.0017, -0.0004) 0.002135	-0.0011 (-0.0017, -0.0005) 0.000712	-0.0004 (-0.0011, 0.0002) 0.198245
	40≤Aged<50	-0.0006 (-0.0012, -0.0001) 0.032023	-0.0009 (-0.0014, -0.0003) 0.001909	-0.0001 (-0.0007, 0.0005) 0.673213
	50≤Aged<60	-0.0008 (-0.0014, -0.0001) 0.021113	-0.0011 (-0.0017, -0.0004) 0.001188	0.0000 (-0.0007, 0.0007) 0.906714
	60≤Aged	-0.0009 (-0.0015, -0.0002) 0.007393	-0.0011 (-0.0017, -0.0004) 0.001304	-0.0004 (-0.0010, 0.0003) 0.281805
Trochanter BMD	20≤Aged<30	-0.0003 (-0.0009, 0.0003) 0.348101	-0.0005 (-0.0011, 0.0001) 0.113008	-0.0001 (-0.0008, 0.0006) 0.827111
	30≤Aged<40	-0.0008 (-0.0014, -0.0003) 0.004504	-0.0009 (-0.0014, -0.0003) 0.001459	-0.0004 (-0.0010, 0.0002) 0.155924
	40≤Aged<50	-0.0003 (-0.0008, 0.0002) 0.278418	-0.0004 (-0.0010, 0.0001) 0.101470	0.0001 (-0.0005, 0.0007) 0.672573
	50≤Aged<60	-0.0009 (-0.0016, -0.0002) 0.009191	-0.0012 (-0.0019, -0.0005) 0.000699	-0.0004 (-0.0011, 0.0004) 0.364990
	60≤Aged	-0.0004 (-0.0010, 0.0002) 0.201940	-0.0005 (-0.0011, 0.0001) 0.106856	-0.0001 (-0.0007, 0.0005) 0.713744
Intertrochanter BMD	20≤Aged<30	-0.0007 (-0.0016, 0.0001) 0.094572	-0.0011 (-0.0019, -0.0002) 0.011121	0.0001 (-0.0008, 0.0010) 0.769779
	30≤Aged<40	-0.0018 (-0.0026, -0.0011) 0.000003	-0.0019 (-0.0027, -0.0012) <0.000001	-0.0011 (-0.0019, -0.0003) 0.005767
	40≤Aged<50	-0.0008 (-0.0015, -0.0001) 0.022436	-0.0011 (-0.0018, -0.0004) 0.002459	0.0001 (-0.0006, 0.0009) 0.769447
	50≤Aged<60	-0.0016 (-0.0025, -0.0007) 0.000748	-0.0019 (-0.0028, -0.0010) 0.000042	-0.0007 (-0.0016, 0.0003) 0.190718
	60≤Aged	-0.0015 (-0.0023, -0.0007) 0.000390	-0.0017 (-0.0025, -0.0008) 0.000101	-0.0007 (-0.0015, 0.0001) 0.102944
Total spine BMD	20≤Aged<30	-0.0002 (-0.0009, 0.0004) 0.432167	-0.0005 (-0.0011, 0.0002) 0.141290	0.0000 (-0.0007, 0.0007) 0.984658
	30≤Aged<40	-0.0006 (-0.0012, -0.0000) 0.045489	-0.0007 (-0.0013, -0.0001) 0.021858	-0.0002 (-0.0009, 0.0005) 0.545599
	40≤Aged<50	0.0000 (-0.0006, 0.0006) 0.894495	-0.0002 (-0.0008, 0.0004) 0.520570	0.0006 (-0.0001, 0.0012) 0.086857
	50≤Aged<60	-0.0013 (-0.0021, -0.0005) 0.001560	-0.0017 (-0.0025, -0.0009) 0.000021	-0.0007 (-0.0016, 0.0002) 0.109719
	60≤Aged	-0.0006 (-0.0013, 0.0002) 0.140196	-0.0007 (-0.0015, 0.0000) 0.051753	-0.0006 (-0.0014, 0.0002) 0.150883
L1 BMD	20≤Aged<30	-0.0002 (-0.0008, 0.0005) 0.627418	-0.0003 (-0.0010, 0.0003) 0.298880	0.0003 (-0.0004, 0.0010) 0.458371
	30≤Aged<40	-0.0005 (-0.0012, 0.0001) 0.086657	-0.0006 (-0.0012, 0.0000) 0.053243	-0.0001 (-0.0007, 0.0006) 0.858850
	40≤Aged<50	-0.0001 (-0.0008, 0.0005) 0.668590	-0.0003 (-0.0010, 0.0003) 0.274953	0.0005 (-0.0002, 0.0012) 0.125866
	50≤Aged<60	-0.0015 (-0.0023, -0.0007) 0.000174	-0.0019 (-0.0027, -0.0011) 0.000002	-0.0008 (-0.0016, 0.0001) 0.075641
	60≤Aged	-0.0011 (-0.0018, -0.0004) 0.002960	-0.0012 (-0.0019, -0.0005) 0.001050	-0.0008 (-0.0016, -0.0000) 0.037263
L2 BMD	20≤Aged<30	-0.0003 (-0.0010, 0.0003) 0.348527	-0.0005 (-0.0012, 0.0001) 0.117012	-0.0001 (-0.0008, 0.0007) 0.828919
	30≤Aged<40	-0.0007 (-0.0013, -0.0000) 0.046582	-0.0007 (-0.0014, -0.0001) 0.023423	-0.0002 (-0.0009, 0.0005) 0.535701
	40≤Aged<50	-0.0001 (-0.0007, 0.0005) 0.815957	-0.0003 (-0.0009, 0.0003) 0.338671	0.0004 (-0.0003, 0.0011) 0.221228
	50≤Aged<60	-0.0015 (-0.0023, -0.0007) 0.000477	-0.0019 (-0.0027, -0.0011) 0.000008	-0.0011 (-0.0020, -0.0001) 0.024255
	60≤Aged	-0.0005 (-0.0013, 0.0002) 0.180331	-0.0007 (-0.0015, 0.0001) 0.075794	-0.0006 (-0.0014, 0.0002) 0.156083
L3 BMD	20≤Aged<30	-0.0002 (-0.0009, 0.0004) 0.483580	-0.0005 (-0.0011, 0.0002) 0.173354	-0.0001 (-0.0009, 0.0006) 0.722289
	30≤Aged<40	-0.0006 (-0.0013, 0.0000) 0.061670	-0.0007 (-0.0014, -0.0001) 0.029734	-0.0003 (-0.0011, 0.0004) 0.346774
	40≤Aged<50	0.0002 (-0.0005, 0.0008) 0.566619	-0.0001 (-0.0007, 0.0006) 0.870392	0.0006 (-0.0001, 0.0013) 0.104112
	50≤Aged<60	-0.0012 (-0.0021, -0.0004) 0.005873	-0.0017 (-0.0025, -0.0008) 0.000156	-0.0007 (-0.0017, 0.0002) 0.144140
	60≤Aged	-0.0003 (-0.0011, 0.0006) 0.513681	-0.0005 (-0.0013, 0.0004) 0.272575	-0.0002 (-0.0011, 0.0007) 0.668748
L4 BMD	20≤Aged<30	-0.0003 (-0.0009, 0.0004) 0.413254	-0.0005 (-0.0012, 0.0001) 0.124521	0.0000 (-0.0007, 0.0007) 0.999632
	30≤Aged<40	-0.0006 (-0.0012, 0.0001) 0.084888	-0.0006 (-0.0013, -0.0000) 0.045006	-0.0001 (-0.0008, 0.0006) 0.741328
	40≤Aged<50	0.0001 (-0.0005, 0.0008) 0.679172	-0.0001 (-0.0008, 0.0005) 0.722415	0.0007 (-0.0000, 0.0014) 0.058517
	50≤Aged<60	-0.0011 (-0.0019, -0.0002) 0.016075	-0.0016 (-0.0024, -0.0007) 0.000463	-0.0004 (-0.0014, 0.0006) 0.399831
	60≤Aged	-0.0004 (-0.0012, 0.0005) 0.400768	-0.0006 (-0.0014, 0.0003) 0.176298	-0.0006 (-0.0016, 0.0003) 0.171516

Model 1: no covariates were adjusted. Model 2: race/ethnicity (Mexican American; other Hispanic; non-Hispanic white; non-Hispanic black; other races) were adjusted. Model 3: race/ethnicity (Mexican American; other Hispanic; non-Hispanic white; non-Hispanic black; other races), education level (under high school; high school or equivalent; above high school), income to poverty ratio (quartile groups), BMI (obese, overweight, normal), smoking status (less than 100 cigarettes; greater than or equal to 100 cigarettes), alcohol consumption status (had at least 12 alcohol drinks past one year; have less than 12 alcohol drinks past one year), hypertension (yes; no), diabetes (yes; no; borderline), ALT (quartile groups), AST (quartile groups), total calcium (quartile groups), cholesterol (quartile groups), and C-reactive protein (quartile groups) were adjusted. HDL-C high-density lipoprotein cholesterol; BMD bone mineral density; ALT alanine aminotransferase; AST aspartate aminotransferase

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