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Table 7 Two-piecewise linear regression models of HDL-C on bone mineral density in females

From: High-density Lipoprotein Cholesterol Is Negatively Correlated with Bone Mineral Density and Has Potential Predictive Value for Bone Loss

Age Groups

 

Index

20≤Aged<30

 

Total femur BMD

Femur neck BMD

Trochanter BMD

Intertrochanter BMD

Fitting by the standard linear model

-0.0000 (-0.0007, 0.0006) 0.8952

0.0002 (-0.0005, 0.0008) 0.6136

-0.0001 (-0.0007, 0.0004) 0.6102

-0.0001 (-0.0009, 0.0006) 0.7263

Fitting by the two-piecewise linear model

    

Inflection point (mg/dL)

65

65

65

65

HDL-C < Infection point

-0.0011 (-0.0021, -0.0001) 0.0257

-0.0006 (-0.0016, 0.0004) 0.2539

-0.0011 (-0.0019, -0.0002) 0.0141

-0.0013 (-0.0024, -0.0002) 0.0228

HDL-C > Infection point

0.0016 (0.0003, 0.0028) 0.0170

0.0013 (-0.0000, 0.0026) 0.0549

0.0013 (0.0001, 0.0024) 0.0291

0.0016 (0.0002, 0.0031) 0.0298

Log likelihood ratio

0.004

0.05

0.004

0.006

30≤Aged<40

 

Total femur BMD

Femur neck BMD

Trochanter BMD

Intertrochanter BMD

Fitting by the standard linear model

-0.0010 (-0.0017, -0.0004) 0.0021

-0.0009 (-0.0016, -0.0003) 0.0056

-0.0007 (-0.0013, -0.0002) 0.0127

-0.0012 (-0.0019, -0.0004) 0.0023

Fitting by the two-piecewise linear model

    

Inflection point (mg/dL)

45

45

45

45

HDL-C < Infection point

0.0021 (-0.0007, 0.0048) 0.1389

0.0013 (-0.0014, 0.0041) 0.3443

0.0018 (-0.0006, 0.0043) 0.1444

0.0030 (-0.0002, 0.0062) 0.0626

HDL-C > Infection point

-0.0015 (-0.0023, -0.0007) 0.0001

-0.0013 (-0.0020, -0.0005) 0.0013

-0.0012 (-0.0018, -0.0005) 0.0012

-0.0018 (-0.0027, -0.0009) <0.0001

Log likelihood ratio

0.02

0.092

0.031

0.007

50≤Aged<60

 

Total femur BMD

Femur neck BMD

Trochanter BMD

Intertrochanter BMD

Fitting by the standard linear model

-0.0010 (-0.0018, -0.0002) 0.0138

-0.0010 (-0.0018, -0.0003) 0.0077

-0.0007 (-0.0014, -0.0001) 0.0302

-0.0012 (-0.0021, -0.0002) 0.0161

Fitting by the two-piecewise linear model

    

Inflection point (mg/dL)

70

70

70

70

HDL-C < Infection point

-0.0025 (-0.0037, -0.0012) 0.0002

-0.0017 (-0.0030, -0.0005) 0.0073

-0.0015 (-0.0026, -0.0004) 0.0085

-0.0032 (-0.0047, -0.0017) <0.0001

HDL-C > Infection point

0.0008 (-0.0007, 0.0022) 0.2960

-0.0002 (-0.0016, 0.0012) 0.7467

0.0001 (-0.0011, 0.0014) 0.8311

0.0013 (-0.0004, 0.0030) 0.1407

Log likelihood ratio

0.003

0.161

0.084

<0.001

 

L1 BMD

L2 BMD

L3 BMD

L4 BMD

Fitting by the standard linear model

-0.0015 (-0.0025, -0.0006) 0.0021

-0.0012 (-0.0023, -0.0002) 0.0228

-0.0013 (-0.0024, -0.0003) 0.0122

-0.0008 (-0.0018, 0.0002) 0.1087

Fitting by the two-piecewise linear model

    

Inflection point (mg/dL)

70

70

70

70

HDL-C < Infection point

-0.0029 (-0.0044, -0.0013) 0.0004

-0.0030 (-0.0047, -0.0013) 0.0006

-0.0035 (-0.0052, -0.0018) <0.0001

-0.0025 (-0.0041, -0.0009) 0.0023

HDL-C > Infection point

0.0001 (-0.0016, 0.0019) 0.8969

0.0009 (-0.0010, 0.0028) 0.3502

0.0013 (-0.0006, 0.0031) 0.1889

0.0012 (-0.0006, 0.0030) 0.1869

Log likelihood ratio

0.025

0.007

<0.001

0.007

60≤Aged

 

Total femur BMD

Femur neck BMD

Trochanter BMD

Intertrochanter BMD

Fitting by the standard linear model

0.0000 (-0.0009, 0.0009) 0.9655

-0.0001 (-0.0008, 0.0007) 0.8637

0.0002 (-0.0006, 0.0009) 0.6423

-0.0001 (-0.0011, 0.0010) 0.9103

Fitting by the two-piecewise linear model

    

Inflection point (mg/dL)

45

45

45

45

HDL-C < Infection point

0.0076 (0.0031, 0.0121) 0.0010

0.0056 (0.0017, 0.0095) 0.0050

0.0055 (0.0017, 0.0094) 0.0052

0.0096 (0.0041, 0.0151) 0.0007

HDL-C > Infection point

-0.0008 (-0.0018, 0.0002) 0.1095

-0.0007 (-0.0015, 0.0002) 0.1171

-0.0004 (-0.0013, 0.0004) 0.3462

-0.0011 (-0.0023, 0.0001) 0.0716

Log likelihood ratio

<0.001

0.003

0.004

<0.001

  1. Race/ethnicity (Mexican American; other Hispanic; non-Hispanic white; non-Hispanic black; other races), education level (under high school; high school or equivalent; above high school), income to poverty ratio (quartile groups), BMI (obese, overweight, normal), smoking status (less than 100 cigarettes; greater than or equal to 100 cigarettes), alcohol consumption status (had at least 12 alcohol drinks past one year; have less than 12 alcohol drinks past one year), hypertension (yes; no), diabetes (yes; no; borderline), ALT (quartile groups), AST (quartile groups), total calcium (quartile groups), cholesterol (quartile groups), and C-reactive protein (quartile groups) were adjusted. HDL-C high-density lipoprotein cholesterol; BMD bone mineral density; ALT alanine aminotransferase; AST aspartate aminotransferase