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Table 2 Adjusted hazard ratios for incidence of T2DM by the groups of HDL-C levels in the analyses of regression with time-dependent variables

From: Association between high-density lipoprotein cholesterol and type 2 diabetes mellitus among Chinese: the Beijing longitudinal study of aging

  HDL-C (mmol/L)  
< 1.15 1.15–1.39 1.40–1.69 ≥ 1.70
No. of participants 365 361 372 364  
No. of diabetes cases 46 35 20 19  
Incidence/1000 person-years 12.60 9.70 5.38 5.22  
  Hazard ratio (95% confidence interval) P-value
Time-dependent Cox regression
 I 1.00 0.96 (0.62–1.50) 0.46 (0.26–0.78) 0.37 (0.21–0.64) < 0.001
 II 1.00 1.00 (0.64–1.56) 0.49 (0.28–0.85) 0.45 (0.26–0.78) 0.001
 III 1.00 1.04 (0.66–1.64) 0.54 (0.31–0.95) 0.49 (0.28–0.88) 0.006
 IV 1.00 0.98 (0.62–1.55) 0.48 (0.27–0.85) 0.44 (0.25–0.80) 0.002
Time-dependent Fine-Gray model
 I 1.00 0.97 (0.63–1.50) 0.45 (0.26–0.76) 0.39 (0.23–0.67) < 0.001
 II 1.00 1.03 (0.67–1.58) 0.48 (0.28–0.83) 0.48 (0.28–0.82) 0.002
 III 1.00 1.10 (0.70–1.73) 0.56 (0.32–0.99) 0.56 (0.32–0.97) 0.014
 IV 1.00 1.07 (0.68–1.67) 0.52 (0.29–0.92) 0.52 (0.30–0.91) 0.008
  1. BMI, body mass index; FPG, fasting plasma glucose; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; TG, triglycerides
  2. I: Adjustments were made for gender, age, education, smoking status, alcohol intake, regular exercise, residence and job type
  3. II: Model I along with hypertension, BMI, consumptions of staple foods and eggs
  4. III: Model II along with LDL-C, TG, antihypertensive drug and cardiovascular medication use
  5. IV: Model III along with FPG