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Table 1 Demographic, clinical and cognitive characteristics of T2DM patients with or without MCI

From: Inverted U-shaped correlation between serum low-density lipoprotein cholesterol levels and cognitive functions of patients with type 2 diabetes mellitus

 

All individuals (n = 497)

MCI (n = 235)

Non-MCI (n = 262)

P value

Age (year)

60 (53–66)

62 (56–68)

58 (52–64)

<0.001b*

Female (n, %)

207 (41.6)

117 (49.8)

90 (34.4)

<0.001c*

Education

10 (9–12)

9 (6–12)

12 (9–12)

<0.001b*

BMI (Kg/m2)

24.77 (22.77–27.04)

24.57 (22.77–27.12)

24.80 (22.75–26.86)

0.869b

DM Duration (year)

10 (5–14)

10 (5–15)

10 (5–13)

0.352b

HBP Duration (year)

3 (0–10)

5 (0–15)

1 (0–10)

0.006b*

Smoking (n, %)

178 (35.8)

79 (33.6)

99 (37.8)

0.333c

Statins (n, %)

265 (53.3)

133 (56.6)

132 (50.4)

0.166c

Other Antilipidemic Drugs (n, %)

24 (4.8)

15 (6.4)

9 (3.4)

0.126c

HbA1c (%)

8.60 (7.20–10.30)

8.80 (7.50–10.50)

8.40 (7.10–10.10)

0.090b

TG (mmol/l)

1.48 (1.04–2.27)

1.53 (1.00–2.38)

1.48 (1.05–2.18)

0.599b

TC (mmol/l)

4.60 ± 1.15

4.67 ± 1.24

4.54 ± 1.07

0.196a

HDL-C (mmol/l)

1.15 (1.00–1.34)

1.16 (1.01–1.34)

1.15 (0.98–1.32)

0.300b

LDL-C (mmol/l)

2.82 (2.29–3.43)

2.85 (2.23–3.63)

2.81 (2.32–3.24)

0.475b

LDL-C/HDL-C

2.43 (2.00–2.95)

2.43 (1.98–3.03)

2.42 (2.01–2.91)

0.819b

MoCA

26 (23–27)

22 (20–24)

27 (26–28)

<0.001b*

DST

12 (10–13)

11 (9–12)

12 (11–14)

<0.001b*

VFT

16 (14–19)

15 (13–18)

18 (15–21)

<0.001b*

CDT

4 (3–4)

3 (2–4)

4 (3–4)

<0.001b*

TMTA

60 (49–83)

71 (57–95)

55 (45–67)

<0.001b*

TMTB

160 (123–205)

185 (145–236)

135 (106–178)

<0.001b*

  1. Abbreviations: BMI Body mass index, DM Diabetes mellitus, HBP High blood pressure, FPG Fasting plasma glucose, TG Triglycerides, TC Total cholesterol, LDL-C Low density lipoprotein cholesterol, HDL-C High density lipoprotein cholesterol, MoCA Montreal Cognitive Assessment, DST Digit Span Test, VFT Verbal Fluency Test, CDT Clock Drawing Test, TMTA Trail Making Test-A, TMTB Trail Making Test-B, MCI Mild cognitive impairment
  2. The data are presented as n (%), or the median (inter-quartile range) unless otherwise specified
  3. aStudent’s t test was employed for normally distributed variables
  4. bThe Mann-Whitney U test was employed for asymmetrically distributed variables
  5. cThe Chi-square test was employed for categorical variables
  6. *P < 0.05