Table 1 Compilation of severe cutaneous adverse reactions (SCAR) of the skin and subcutaneous tissue of various approved drugs and their metabolites with supposed lysosomotropism (°), confirmed lysosomotropism (blue), no lysosomotropism (red), and photosensitizing (x) [3,4,5,6,7] according to their human medicine european public assessment report (EPAR) product information [8] and https://www.drugs.com. Frequency (CIOMS classification) is given by very common (≥ 1/10) (*), frequent/common (> 1/100, < 1/10) (**), infrequent/uncommon (> 1/1.000, < 1/100) (***), rare (> 1/10.000, < 1/1.000) (****), very rare (< 1/10.000) (*****), and frequency not reported (#)
From: Drug triggered pruritus, rash, papules, and blisters – is AGEP a clash of an altered sphingolipid-metabolism and lysosomotropism of drugs accumulating in the skin?
