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Table 3 The association of APOE genetic polymorphisms with serum lipids in middle-aged and elderly Fujian Han population

From: The effects of genetic polymorphisms of APOE on circulating lipid levels in middle-aged and elderly chinese Fujian Han population: toward age- and sex-personalized management

Allele/ Genotype

N

TC

(m mol/L)

TG

(m mol/L)

HDL-C

(m mol/L)

LDL-C

(m mol/L)

ApoA1

(g/L)

ApoB

(g/L)

A1/B

ε2 carrier

214

4.89±1.02*

1.44±0.91

1.39±0.38

2.84±0.91**

1.42±0.19

0.95±0.23**

1.51±0.43*

ε3 carrier

989

5.16±0.99

1.43±0.97

1.35±0.34

3.29±0.87

1.38±0.18

1.04±0.27

1.36±0.38

ε4 carrier

216

5.31±1.02

1.58±1.01

1.35±0.54

3.31±0.98

1.36±0.11

1.07±0.22

1.28±0.33

ε2/ε2

11

4.51±1.24*

2.05±1.35

1.39±0.33

2.20±0.69** #

1.46±0.16

0.70±0.32* #

2.08±0.92* #

ε2/ε3

176

4.91±1.07*

1.39±0.89

1.40±0.38

2.92±0.90**

1.42±0.20

0.98±0.27*

1.52±0.63*

ε2/ε4

27

4.73±0.98*

1.54±0.87

1.33±0.40

2.83±0.79*

1.39±0.16

1.10±0.30

1.29±0.32

ε3/ε3

989

5.16±0.99

1.43±0.97

1.35±0.34

3.29±0.87

1.38±0.18

1.04±0.27

1.36±0.38

ε3/ε4

199

5.19±1.14

1.59±1.15

1.35±0.56

3.27±0.99

1.36±0.11

1.07±0.42

1.26±0.54

ε4/ε4

17

5.33±0.96

1.44±0.87

1.36±0.33

3.38±0.78

1.38±0.09

1.22±0.23

1.29±0.26

  1. Data are expressed as the mean ± SD. The ε2 carriers included the genotypes ε2/ε2, ε2/ε3 and ε2/ε4; the ε3 carriers included ε3/ε3; the ε4 carriers included ε3/ε4 and ε4/ε4. TC Total cholesterol, TG=Triglyceride, HDL-C High density lipoprotein cholesterol, LDL-C Low density lipoprotein cholesterol. ApoA1 apolipoproteinA1, ApoB apolipoprotein B. A1/B, the ratio of ApoA1 and ApoB
  2. Continuous variables were compared using unadjusted one-way ANOVA, LSD (L) post-test were performed to determine the differences in lipid parameters among different genotypes or alleles
  3. *P<0.05, **P<0.01, ε2 carriers VS noncarriers (ε3 carriers and ε4 carriers); #P<0.05,ε2/ε2 genotype VS ε2/ε3 and ε2/ε4 genotype