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Table 4 The influence of Alleles of APOE and sex in serum lipid profile in middle-aged and elderly Fujian Han population

From: The effects of genetic polymorphisms of APOE on circulating lipid levels in middle-aged and elderly chinese Fujian Han population: toward age- and sex-personalized management

Allele

Male (n=795)

P value

Female (n=624)

P value

ε2 (115)

ε3(563)

ε4(117)

ε2(99)

ε3(426)

ε4(99)

TC

4.69±1.01*

5.03±0.94

5.07±0.98

0.030

5.14±1.01

5.22±0.99

5.53±0.97

0.172

TG

1.62±1.05

1.55±1.04

1.63±1.08

0.853

1.18±0.57

1.23±0.65

1.45±0.70

0.114

HDL-C

1.25±0.28

1.27±0.30

1.18±0.24

0.182

1.60±0.41

1.48±0.35

1.53±0.71

0.363

LDL-C

2.70±0.92**

3.27±0.89

3.29±0.86

<0.001

2.98±0.86*

3.29±0.84

3.35±0.94

0.037

ApoA1

1.37±0.14

1.35±0.15

1.33±0.10

0.278

1.48±0.24

1.43±0.20

1.41±0.11

0.206

ApoB

0.93±0.19*

1.04±0.23

1.05±0.23

0.024

0.94±0.24*

0.99±0.28

1.09±0.29

0.015

A1/B

1.58±0.37*

1.37±0.52

1.30±0.39

0.038

1.72±0.58*

1.54±0.53

1.36±0.45

0.029

Genotype

ε2/ε2 (7)

ε2/ε3(92)

ε2/ε4(16)

 

ε2/ε2(4)

ε2/ε3(84)

ε2/ε4(11)

 

TC

4.95±1.09

4.70±1.07

4.55±0.63

0.315

3.64±0.62

5.19±1.02#

5.08±0.91#

0.038

TG

1.67±1.31

1.59±1.04

1.55±0.92

0.202

0.94±0.31

1.14±0.53

1.52±0.90

0.156

HDL-C

1.31±0.36

1.26±0.26

1.22±0.37

0.436

1.42±0.31

1.61±0.42

1.56±0.39

0.765

LDL-C

1.77±0.33

2.81±0.94##

2.67±0.49#

<0.001

2.95±0.64

3.07±0.84#

3.19±0.81#

0.036

ApoA1

1.39±0.12

1.38±0.15

1.32±0.11

0.590

1.55±0.14

1.46±0.25

1.54±0.19

0.491

ApoB

0.76±0.11

0.98±0.29#

1.14±0.31#

0.038

0.79±0.50

0.97±0.29##

1.02±0.29#

0.002

A1/B

2.11±0.33

1.49±0.67#

1.16±0.37##

0.043

2.12±0.68

1.72±0.69##

1.71±0.52##

<0.001

  1. Data are expressed as the mean ± SD. TC Total cholesterol, TG Triglyceride, HDL-C High density lipoprotein cholesterol, LDL-C Low density lipoprotein cholesterol. ApoA1 apolipoproteinA1, ApoB apolipoprotein B. A1/B, the ratio of ApoA1 and ApoB. Values were compared using unadjusted one-way ANOVA, LSD (L) post-test were performed to compare the differences in lipid parameters among different carriers
  2. *P<0.05, **P<0.01, ε2 carriers VS noncarriers (ε3 carriers and ε4 carriers); #P<0.05,##P<0.01, compared with the ε2/ε2 genotype