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Table 5 The effects of APOE, age, and sex in serum lipid profile in middle-aged and elderly Fujian Han population

From: The effects of genetic polymorphisms of APOE on circulating lipid levels in middle-aged and elderly chinese Fujian Han population: toward age- and sex-personalized management

serum

lipids

Male (795)

Female (624)

all

ε2 (115)

ε3(563)

ε4(117)

all

ε2 (99)

ε3(426)

ε4(99)

40-64

 N=481

 N=65

 N=350

 N=66

 N=355

 N=54

 N=244

N=57

TC

5.09±0.93

4.85±0.86*

5.14±0.92

5.06±1.02

5.20±0.99

5.12±0.97

5.19±1.02

5.33±0.95

TG

1.75±1.25

1.78±1.13

1.72±1.20

1.93±1.33

1.19±0.65

1.14±0.57

1.16±0.71

1.34±0.45

HDL-C

1.23±0.27

1.25±0.29

1.25±0.27

1.14±0.22#

1.52±0.36

1.65±0.42*

1.49±0.33

1.53±0.41

LDL-C

3.31±0.91

2.84±0.74*

3.41±0.91

3.26±0.94

3.23±0.86

3.01±0.78

3.25±0.87

3.34±0.88

ApoA1

1.35±0.15

1.38±0.17

1.35±0.15

1.30±0.10#

1.44±0.20

1.52±0.26*

1.42±0.21

1.43±0.11

ApoB

1.12±0.38

1.01±0.24*

1.12±0.34

1.25±0.61

1.05±0.28

0.98±0.28

1.04±0.28

1.07±0.28

A1/B

1.29±0.46

1.39±0.46*

1.28±0.43

1.27±0.64

1.44±0.54

1.66±0.46*

1.44±0.52

1.32±0.48

65+

N=314

 N=50

 N=213

 N=51

 N=269

 N=45

 N=182

 N=42

TC

4.63±0.95

4.35±1.16

4.71±0.91

4.60±0.86

5.30±1.11

5.17±1.12

5.32±0.95

5.33±1.02

TG

1.22±0.83

1.40±0.83

1.19±0.91

1.15±0.85

1.46±0.72

1.24±0.59

1.38±0.53

1.82±0.84#

HDL-C

1.29±0.33

1.23±0.27

1.31±0.35

1.27±0.24

1.48±0.59

1.49±0.38

1.47±0.42

1.53±0.61

LDL-C

2.90±0.88

2.36±1.17**

2.99±0.79

3.09±0.85

3.34±0.98

3.09±0.94

3.39±0.77

3.38±0.88

ApoA1

1.34±0.12

1.35±0.08

1.33±0.14

1.36±0.09

1.41±0.18

1.40±0.15

1.43±0.19

1.37±0.12

ApoB

1.19±0.31

1.08±0.38*

1.19±0.29

1.26±0.25

1.22±0.29

1.17±0.41

1.22±0.25

1.27±0.32

A1/B

1.03±0.68

1.26±0.54*

1.04±0.64

1.02±0.46

1.11±0.59

1.11±0.45

1.12±0.50

1.08±0.38

  1. Data are expressed as the mean ± SD.TC Total cholesterol, TG Triglyceride, HDL-C High density lipoprotein cholesterol, LDL-C Low density lipoprotein cholesterol. ApoA1 apolipoproteinA, ApoB apolipoprotein B. A1/B, the ratio of ApoA1 and ApoB. Values were compared using unadjusted one-way ANOVA, LSD (L) post-test were performed to determine the differences in lipid parameters among different allele carriers
  2. *P<0.05, **P<0.01, ε2 carriers VS noncarriers (ε3 carriers and ε4 carriers); #P<0.05, ε4 carriers VS noncarriers (ε3 carriers and ε2 carriers)