Table 4 Associations of mean, visit-to-visit variability and trajectory of LDL-c with incident T2DM

Mean level

< 3.37 mmol/L

3354 (145)

1.00 (ref)

1.00 (ref)

≥3.37 mmol/L

1121 (78)

1.54 (1.17-2.03)

0.002

1.12 (0.85-1.49)

0.426

Total

Quartiles of the mean level (mmol/L)

Q1 (0.00,2.49)

1125 (44)

1.00 (ref)

1.00 (ref)

Q2 (2.50,2.92)

1109 (47)

1.16 (0.77-1.75)

0.477

1.02 (0.68-1.55)

0.920

Q3 (2.93,3.37)

1119 (54)

1.25 (0.84-1.87)

0.265

1.09 (0.73-1.63)

0.684

Q4 (3.38,6.57)

1122 (78)

1.75 (1.21-2.53)

0.003

1.16 (0.80-1.70)

0.432

P_trend

0.004

0.015

0.848

Per 1-unit increase

1.30 (1.08-1.56)

0.005

1.02 (0.84-1.23)

0.859

Quartiles of SD

Q1 (0.01,0.21)

1107 (39)

1.00 (ref)

1.00 (ref)

Q2 (0.22,0.30)

1084 (50)

1.36 (0.90-2.07)

0.146

1.30 (0.85-1.98)

0.224

Q3 (0.31,0.42)

1195 (59)

1.41 (0.94-2.11)

0.098

1.09 (0.72-1.63)

0.688

Q4 (0.43,1.71)

1084 (75)

1.87 (1.27-2.75)

0.002

1.18 (0.80-1.76)

0.404

P_trend

0.003

0.016

0.633

Trajectories

Low

648 (30)

1.00 (ref)

1.00 (ref)

Moderate

1915 (79)

0.95 (0.62-1.45)

0.808

0.78 (0.51-1.19)

0.250

Moderate-high

1527 (86)

1.23 (0.81-1.86)

0.337

0.91 (0.59-1.38)

0.642

High

3385 (28)

1.51 (0.90-2.53)

0.116

0.86 (0.51-1.45)

0.574

P_trend

0.033

0.124

0.654

Exclusion of prediabetes

Quartiles of the mean level (mmol/L)

Q1 (0.00,2.49)

1064 (20)

1.00 (ref)

1.00 (ref)

Q2 (2.50,2.92)

1057 (25)

1.34 (0.75-2.42)

0.328

1.15 (0.64-2.08)

0.647

Q3 (2.93,3.36)

1034 (26)

1.34 (0.75-2.39)

0.331

1.16 (0.65-2.09)

0.617

Q4 (3.37,6.57)

1055 (46)

2.28 (1.35-3.86)

0.002

1.63 (0.95-2.78)

0.074

Trajectories

Low

609 (15)

1.00 (ref)

1.00 (ref)

Moderate

1797 (36)

0.86 (0.47-1.57)

0.623

0.76 (0.41-1.39)

0.372

Moderate-high

1448 (48)

1.34 (0.75-2.39)

0.322

1.02 (0.57-1.84)

0.944

High

356 (18)

2.01 (1.01-3.99)

0.046

1.31 (0.65-2.62)

0.451