Fig. 1

The expression pattern of 15-LOX and its related metabolites in breast tumor and normal tissues, the blood of patients and healthy subjects, and breast cancer cell lines. The local and circulating level of 15-LOX enzymes and their main metabolites is different in patients with breast cancer and healthy subjects. The 15-LOX and its metabolite levels are shown in healthy subjects (The bottom right of the image) and patients with breast cancer (The bottom left of the image). The expression level of the 15-LOX and the metabolites in the serum and tissue samples of individuals is shown separately. The decreasing level of 15-LOX-1, − 2 transcripts, and 15-HETE in breast tumor tissue was accompanied by the elevated level of PPARγ [17, 21, 25]. Besides the increasing level of 15-HODE, 9-HODE, 13-HOTrE, 9-HOTrE, and 12-HHTre was apparent in breast cancer patients versus the elevated level of 15-HETE in serum of healthy subjects [26, 36, 40]. 15-LOX activation through exogenous 15-HETE and 13-HODE administration leads to breast cancer cell proliferation and invasion that is illustrated in breast cancer cells (Top left of the image) and breast normal cells (top right of the image) [25, 40]